HitPredict

Interactor 1: LEG1 (P09382)
Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)
Gene: LGALS1

Interactor 2: PTPRZ (P23471)
Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2)
Gene: PTPRZ1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	18838383, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 135 Hs			1 2315
+	Hs
		572282 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		PTPRZ_HUMAN (1-2315): 0: 1711: 100.00
+	Hs
		449193 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		PTPRG_HUMAN (28-665): 1.12e-131: 454: 27.26
+	Hs
		572281 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		PTPRG_HUMAN (28-665): 1.12e-131: 454: 27.26
+	Hs
		121108 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		PTPRG_HUMAN (28-665): 1.12e-131: 454: 27.26
+	Hs
		449191 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		PTPRB_HUMAN (1801-2310): 3.65e-109: 391: 23.82
+	Hs
		449248 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		PTPRJ_HUMAN (1995-2289): 4.87e-102: 362: 27.33
+	Hs
		449266 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		PTPRK_HUMAN (1998-2314): 2.28e-101: 362: 24.30
+	Hs
		441165 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		PTPRC_HUMAN (1337-2314): 1.65e-99: 354: 14.06
+	Hs
		572351 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		PTPRJ_HUMAN (1995-2289): 4.87e-102: 362: 27.33
+	Hs
		572363 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		PTPRK_HUMAN (1998-2314): 2.28e-101: 362: 24.30
+	Hs
		449184 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		PTPRA_HUMAN (2023-2314): 3.27e-103: 353: 26.33
+	Hs
		572277 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		PTPRA_HUMAN (2023-2314): 3.27e-103: 353: 26.33
+	Hs
		572368 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		PTPRO_HUMAN (1998-2280): 1.35e-97: 347: 28.03
+	Hs
		814938 LEG7_HUMAN (1-132): 1.27e-43: 141: 33.58		PTPRJ_HUMAN (1995-2289): 4.87e-102: 362: 27.33
+	Hs
		814954 LEG7_HUMAN (1-132): 1.27e-43: 141: 33.58		PTPRK_HUMAN (1998-2314): 2.28e-101: 362: 24.30
+	Hs
		1069959 LEG12_HUMAN (6-134): 8.15e-40: 137: 24.64		PTPRK_HUMAN (1998-2314): 2.28e-101: 362: 24.30
+	Hs
		121146 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		PTPRJ_HUMAN (1995-2289): 4.87e-102: 362: 27.33
+	Hs
		577052 LEG12_HUMAN (6-134): 8.15e-40: 137: 24.64		PTPRA_HUMAN (2023-2314): 3.27e-103: 353: 26.33
+	Hs
		121103 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		PTPRA_HUMAN (2023-2314): 3.27e-103: 353: 26.33
+	Hs
		449192 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		PTPRD_HUMAN (237-431): 1.55e-15: 85.5: 18.91