HitPredict

Interactor 1: LEG1 (P09382)
Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)
Gene: LGALS1

Interactor 2: ITA3 (P26006)
Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]
Gene: ITGA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	30021884, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043236 - laminin binding GO:0070062 - extracellular exosome GO:0098609 - cell-cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 135 Hs			1 1051
+	Hs
		449190 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA6_HUMAN (11-1043): 0: 1027: 35.75
+	Hs
		449257 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA7_HUMAN (1-1043): 0: 1001: 33.85
+	Hs
		449259 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA9_HUMAN (29-1046): 0: 910: 23.72
+	Hs
		449172 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA4_HUMAN (3-1050): 0: 898: 22.77
+	Hs
		449225 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA8_HUMAN (1-1042): 0: 886: 26.12
+	Hs
		121095 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		ITA4_HUMAN (3-1050): 0: 898: 22.77
+	Hs
		419138 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITAV_HUMAN (30-1021): 0: 854: 25.26
+	Hs
		443022 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA5_HUMAN (7-1038): 0: 819: 25.67
+	Hs
		121078 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		ITAV_HUMAN (30-1021): 0: 854: 25.26
+	Hs
		443032 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		ITA5_HUMAN (7-1038): 0: 819: 25.67
+	Hs
		443090 LEG12_HUMAN (6-134): 8.15e-40: 137: 24.64		ITA5_HUMAN (7-1038): 0: 819: 25.67
+	Hs
		121084 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		ITA5_HUMAN (7-1038): 0: 819: 25.67
+	Mm
		139224 LEG9_MOUSE (5-133): 5.75e-38: 133: 27.21		ITA2B_MOUSE (19-1026): 0: 786: 25.72
+	Hs
		449228 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA1_HUMAN (1-171): 1.12e-34: 146: 23.56
+	Hs
		449180 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA2_HUMAN (4-187): 2.16e-34: 145: 25.81
+	Hs
		572330 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		ITA1_HUMAN (1-171): 1.12e-34: 146: 23.56
+	Hs
		566849 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		ITA2_HUMAN (4-187): 2.16e-34: 145: 25.81
+	Hs
		506097 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		ITAM_HUMAN (17-183): 7.99e-27: 120: 20.59
+	Hs
		121102 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		ITA2_HUMAN (4-187): 2.16e-34: 145: 25.81
+	Hs
		121106 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		ITAL_HUMAN (11-190): 1.16e-29: 129: 22.22