HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: HXD8 (P13378)
Homeobox protein Hox-D8 (Homeobox protein Hox-4E) (Homeobox protein Hox-5.4)
Gene: HOXD8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	8890171
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 290
+	Hs
		449556 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		HXD10_HUMAN (59-260): 3.3e-33: 126: 28.29
+	Hs
		449499 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		HXC6_HUMAN (60-273): 1.21e-30: 116: 30.09
+	Hs
		175757 HMGB3_HUMAN (13-181): 1.02e-42: 144: 71.60		MEOX1_HUMAN (27-280): 7.75e-32: 120: 22.05
+	Hs
		175781 HMGB3_HUMAN (13-181): 1.02e-42: 144: 71.60		Q6FHY5_HUMAN (10-281): 2.5e-30: 117: 19.85
+	Dm
		668309 Q9VUD3_DROME (2-95): 4.18e-28: 112: 21.28		ABDA_DROME (91-281): 1.89e-40: 149: 34.56
+	Dm
		115535 M9PFG6_DROME (7-95): 5.32e-26: 105: 21.35		ABDA_DROME (91-281): 1.89e-40: 149: 34.56
+	Dm
		114546 M9PCZ7_DROME (3-84): 4.91e-25: 104: 23.17		ABDA_DROME (91-281): 1.89e-40: 149: 34.56
+	Dm
		950090 Q9VUD3_DROME (2-95): 4.18e-28: 112: 21.28		UBX_DROME (43-257): 3.27e-37: 137: 32.27
+	Dm
		115538 M9PFG6_DROME (7-95): 5.32e-26: 105: 21.35		UBX_DROME (43-257): 3.27e-37: 137: 32.27
+	Dm
		114548 M9PCZ7_DROME (3-84): 4.91e-25: 104: 23.17		UBX_DROME (43-257): 3.27e-37: 137: 32.27
+	Dm
		668228 SOX15_DROME (7-89): 2.14e-20: 90.5: 14.46		ABDA_DROME (91-281): 1.89e-40: 149: 34.56
+	Hs
		595592 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		HXA5_HUMAN (1-269): 3.36e-37: 134: 24.82
+	Hs
		449564 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		HXA10_HUMAN (194-260): 3.74e-15: 77: 62.69
+	Hs
		567820 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		HXB9_HUMAN (1-262): 9.08e-32: 120: 27.10
+	Hs
		818455 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		ALX4_HUMAN (8-282): 2.25e-30: 119: 17.23
+	Hs
		595639 SOX17_HUMAN (10-90): 2.4e-12: 67.1: 19.75		HXA5_HUMAN (1-269): 3.36e-37: 134: 24.82
+	Mm
		192288 SOX15_MOUSE (7-95): 6.28e-14: 69.8: 23.60		ALX4_MOUSE (8-282): 3.38e-32: 124: 19.37
+	Hs
		882164 HM20B_HUMAN (64-165): 1.22e-15: 76: 32.35		GSC_HUMAN (75-284): 8.75e-31: 117: 20.00
+	Hs
		567874 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		HXB9_HUMAN (1-262): 9.08e-32: 120: 27.10
+	Mm
		981834 SOX8_MOUSE (7-86): 6.77e-22: 94.4: 18.75		HXC4_MOUSE (173-256): 1.03e-16: 79.7: 52.13