HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: NUCL (P19338)
Nucleolin (Protein C23)
Gene: NCL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	29721183, 36585612
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 710
+	Hs
		582131 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00
+	Hs
		516365 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55
+	Sc
		376710 IXR1_YEAST (79-174): 6.78e-16: 77.4: 23.96		PABP_YEAST (181-555): 3.61e-53: 194: 17.47
+	Hs
		818011 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		PABP4_HUMAN (222-488): 1.86e-42: 165: 14.88
+	Sc
		514242 NHP6B_YEAST (73-164): 1.14e-21: 87.1: 42.39		PUB1_YEAST (475-648): 4.1e-16: 83.6: 28.89