HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: HMGB2 (P26583)
High mobility group protein B2 (High mobility group protein 2) (HMG-2)
Gene: HMGB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.915

The method score is based on:

Property Details
Experiments 24981860, 33961781, 34349018, 35235311, 12517784
Identification Methods affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HMG_box~HMG_box, HMG_box~HMG_box_2, HMG_box_2~HMG_box_2
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000400 - four-way junction DNA binding
GO:0000793 - condensed chromosome
GO:0000976 - transcription cis-regulatory region binding
GO:0002437 - inflammatory response to antigenic stimulus
and 21 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 215
Hs

1 209
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024