HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: SMCA1 (P28370)
Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)
Gene: SMARCA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	29721183
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 1054
+	Hs
		658657 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		SMCA1_HUMAN (1-1054): 0: 1130: 100.00
+	Hs
		229284 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		SMCA5_HUMAN (32-1051): 0: 1065: 81.86
+	Hs
		229376 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		SMCA5_HUMAN (32-1051): 0: 1065: 81.86
+	Hs
		229339 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		SMCA5_HUMAN (32-1051): 0: 1065: 81.86
+	Hs
		996636 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		CHD3_HUMAN (31-954): 0: 791: 28.94
+	Hs
		996673 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Hs
		817986 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		CHD3_HUMAN (31-954): 0: 791: 28.94
+	Hs
		1311936 SOX7_HUMAN (65-181): 1.3e-28: 112: 19.66		CHD7_HUMAN (3-1046): 0: 780: 26.74
+	Hs
		818056 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Hs
		818279 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		CHD6_HUMAN (1-1039): 0: 750: 26.80
+	Hs
		151490 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		CHD2_HUMAN (21-1047): 0: 732: 29.60
+	Hs
		818102 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		CHD9_HUMAN (2-1019): 0: 741: 26.94
+	Hs
		151405 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		CHD1_HUMAN (5-1050): 0: 695: 29.33
+	Hs
		846944 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		SMCA4_HUMAN (60-913): 0: 686: 31.42
+	Hs
		847069 SOX7_HUMAN (65-181): 1.3e-28: 112: 19.66		SMCA4_HUMAN (60-913): 0: 686: 31.42
+	Hs
		817810 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		SMCA4_HUMAN (60-913): 0: 686: 31.42
+	Hs
		643272 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		SMCA2_HUMAN (170-669): 1.05e-122: 413: 44.32
+	Hs
		996750 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		CHD1L_HUMAN (183-755): 2.35e-132: 424: 43.06
+	Hs
		846863 SOX7_HUMAN (65-181): 1.3e-28: 112: 19.66		SMCA2_HUMAN (170-669): 1.05e-122: 413: 44.32
+	Hs
		817809 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		SMCA2_HUMAN (170-669): 1.05e-122: 413: 44.32