HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: HXA10 (P31260)
Homeobox protein Hox-A10 (Homeobox protein Hox-1.8) (Homeobox protein Hox-1H) (PL)
Gene: HOXA10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	31694235
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 410
+	Hs
		449556 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		HXD10_HUMAN (21-410): 2.98e-37: 139: 38.72
+	Hs
		449499 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		HXC6_HUMAN (196-395): 7.92e-30: 117: 28.00
+	Hs
		449555 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		HXD9_HUMAN (327-388): 2.45e-20: 93.2: 79.03
+	Hs
		449565 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		HXD11_HUMAN (324-406): 2.3e-19: 90.1: 56.63
+	Hs
		818455 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		ALX4_HUMAN (248-408): 7.12e-34: 132: 22.98
+	Hs
		449512 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		HXD8_HUMAN (333-399): 2.09e-16: 80.9: 62.69
+	Dm
		950090 Q9VUD3_DROME (2-95): 4.18e-28: 112: 21.28		UBX_DROME (184-394): 1.34e-27: 114: 26.07
+	Hs
		198797 SOX8_HUMAN (7-89): 7.32e-22: 94.4: 18.07		HXC11_HUMAN (271-406): 1.3e-33: 129: 39.01
+	Mm
		981834 SOX8_MOUSE (7-86): 6.77e-22: 94.4: 18.75		HXC4_MOUSE (192-410): 9.98e-33: 125: 26.03
+	Dm
		115538 M9PFG6_DROME (7-95): 5.32e-26: 105: 21.35		UBX_DROME (184-394): 1.34e-27: 114: 26.07
+	Hs
		567820 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		HXB9_HUMAN (158-398): 1.07e-29: 117: 31.54
+	Dm
		114548 M9PCZ7_DROME (3-84): 4.91e-25: 104: 23.17		UBX_DROME (184-394): 1.34e-27: 114: 26.07
+	Hs
		595592 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		HXA5_HUMAN (151-408): 4.51e-26: 107: 24.35
+	Hs
		617325 SP100_HUMAN (25-178): 1.23e-34: 131: 87.66		ZFHX4_HUMAN (231-406): 2.48e-10: 64.8: 15.82
+	Dm
		668309 Q9VUD3_DROME (2-95): 4.18e-28: 112: 21.28		ABDA_DROME (337-396): 2.03e-16: 83.2: 68.33
+	Dm
		115535 M9PFG6_DROME (7-95): 5.32e-26: 105: 21.35		ABDA_DROME (337-396): 2.03e-16: 83.2: 68.33
+	Dm
		114546 M9PCZ7_DROME (3-84): 4.91e-25: 104: 23.17		ABDA_DROME (337-396): 2.03e-16: 83.2: 68.33
+	Hs
		1199928 SOX7_HUMAN (65-181): 1.3e-28: 112: 19.66		ZFHX4_HUMAN (231-406): 2.48e-10: 64.8: 15.82
+	Dm
		668228 SOX15_DROME (7-89): 2.14e-20: 90.5: 14.46		ABDA_DROME (337-396): 2.03e-16: 83.2: 68.33
+	Hs
		818205 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		ZFHX4_HUMAN (231-406): 2.48e-10: 64.8: 15.82