HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: PRDX2 (P32119)
Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2)
Gene: PRDX2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 198
+	Hs
		643246 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		PRDX3_HUMAN (2-198): 8.33e-101: 293: 63.45
+	Hs
		685636 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		PRDX2_HUMAN (1-198): 3.46e-104: 299: 100.00
+	Hs
		817961 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		PRDX1_HUMAN (1-197): 7.49e-100: 288: 77.78
+	Hs
		685750 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		PRDX2_HUMAN (1-198): 3.46e-104: 299: 100.00
+	Hs
		989368 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		PRDX1_HUMAN (1-197): 7.49e-100: 288: 77.78
+	Hs
		1026752 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		PRDX4_HUMAN (5-198): 2.62e-96: 282: 70.10
+	Sc
		705873 IXR1_YEAST (79-174): 6.78e-16: 77.4: 23.96		TSA1_YEAST (6-198): 1.78e-89: 262: 66.84
+	Hs
		670675 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		PRDX6_HUMAN (4-196): 1.88e-67: 207: 29.13
+	Hs
		670752 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		PRDX6_HUMAN (4-196): 1.88e-67: 207: 29.13