HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: MP2K2 (P36507)
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
Gene: MAP2K2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005783 - endoplasmic reticulum
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 400
+	Hs
		449685 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		MP2K1_HUMAN (2-399): 2.32e-128: 376: 78.14
+	Hs
		449545 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16
+	Hs
		625125 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16
+	Dm
		1213418 Q9VUD3_DROME (2-95): 4.18e-28: 112: 21.28		AKT1_DROME (53-350): 7.38e-123: 370: 21.77
+	Hs
		414690 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		CDK1_HUMAN (69-375): 8.1e-111: 328: 24.76
+	Hs
		414748 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		CDK1_HUMAN (69-375): 8.1e-111: 328: 24.76
+	Hs
		681734 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12
+	Hs
		1298808 TOX2_HUMAN (91-183): 1.82e-20: 90.6: 26.88		AKT3_HUMAN (20-351): 6.4e-123: 365: 20.45
+	Hs
		643349 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		KS6A1_HUMAN (1-347): 1.75e-92: 295: 19.33
+	Hs
		414816 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		CDK1_HUMAN (69-375): 8.1e-111: 328: 24.76
+	Hs
		567641 UBF1_HUMAN (49-205): 2.54e-09: 58.2: 20.00		CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16
+	Hs
		415030 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		CDK1_HUMAN (69-375): 8.1e-111: 328: 24.76
+	Hs
		414863 TFAM_HUMAN (95-186): 2.95e-09: 57.1: 17.39		CDK1_HUMAN (69-375): 8.1e-111: 328: 24.76
+	Hs
		153085 SP100_HUMAN (25-178): 1.23e-34: 131: 87.66		MP2K7_HUMAN (39-383): 1.39e-58: 198: 34.82