HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: RS6 (P62753)
Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33)
Gene: RPS6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	29721183, 34079125
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005783 - endoplasmic reticulum GO:0043065 - positive regulation of apoptotic process
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 249
+	Hs
		643300 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		RS6_HUMAN (1-249): 9.61e-112: 322: 100.00
+	Hs
		817885 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		RS6_HUMAN (1-249): 9.61e-112: 322: 100.00
+	Hs
		916784 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		RS6_HUMAN (1-249): 9.61e-112: 322: 100.00
+	Hs
		567666 UBF1_HUMAN (49-205): 2.54e-09: 58.2: 20.00		RS6_HUMAN (1-249): 9.61e-112: 322: 100.00
+	Sc
		480016 IXR1_YEAST (79-174): 6.78e-16: 77.4: 23.96		RS6A_YEAST (1-239): 1.54e-97: 286: 62.76