HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	29721183
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 288
+	Hs
		449716 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06
+	Hs
		996656 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06
+	Hs
		516365 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		PABP1_HUMAN (109-246): 8.28e-22: 96.8: 21.99
+	Hs
		925013 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00
+	Hs
		996931 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		RBM22_HUMAN (2-287): 6.71e-33: 126: 15.91
+	Hs
		449723 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Mm
		857305 HMGB1_MOUSE (1-174): 9.92e-46: 152: 100.00		TIA1_MOUSE (113-248): 1.05e-17: 84.1: 18.42
+	Hs
		175777 HMGB3_HUMAN (13-181): 1.02e-42: 144: 71.60		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		817896 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00
+	Hs
		996959 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91
+	Hs
		617301 SP100_HUMAN (25-178): 1.23e-34: 131: 87.66		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		996668 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		818011 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		PABP4_HUMAN (109-246): 4.69e-22: 97.6: 21.28
+	Hs
		617298 SP100_HUMAN (25-178): 1.23e-34: 131: 87.66		HNRPD_HUMAN (106-178): 6.05e-11: 64: 26.03
+	Hs
		817926 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		TIAR_HUMAN (73-272): 5.47e-20: 90.6: 14.00
+	Hs
		680429 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		TIA1_HUMAN (113-248): 8.75e-18: 84.1: 18.42
+	Hs
		996662 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		HNRPD_HUMAN (106-178): 6.05e-11: 64: 26.03
+	Sc
		376710 IXR1_YEAST (79-174): 6.78e-16: 77.4: 23.96		PABP_YEAST (98-206): 7.98e-20: 91.1: 19.27
+	Hs
		1054521 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Mm
		639837 UBF1_MOUSE (49-203): 2.84e-09: 58.2: 20.25		TIAR_MOUSE (112-270): 5.86e-18: 84.8: 17.77