HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: TR150 (Q9Y2W1)
Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)
Gene: THRAP3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	29721183, 35235311
Identification Methods	affinity chromatography technology, cross-linking study, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 955
+	Hs
		643417 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		TR150_HUMAN (1-955): 9.81e-127: 408: 100.00
+	Hs
		996972 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		TR150_HUMAN (1-955): 9.81e-127: 408: 100.00
+	Hs
		818633 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		TR150_HUMAN (1-955): 9.81e-127: 408: 100.00
+	Hs
		1301011 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		TR150_HUMAN (1-955): 9.81e-127: 408: 100.00
+	Hs
		449825 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		BCLF1_HUMAN (38-949): 3.55e-78: 276: 33.19
+	Hs
		996936 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		BCLF1_HUMAN (38-949): 3.55e-78: 276: 33.19
+	Hs
		818533 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		BCLF1_HUMAN (38-949): 3.55e-78: 276: 33.19
+	Hs
		996739 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		RBBP6_HUMAN (20-841): 1.66e-72: 264: 13.81
+	Hs
		1300965 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		BCLF1_HUMAN (38-949): 3.55e-78: 276: 33.19
+	Hs
		959073 TFAM_HUMAN (95-186): 2.95e-09: 57.1: 17.39		BCLF1_HUMAN (38-949): 3.55e-78: 276: 33.19
+	Hs
		818019 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		MYO9B_HUMAN (113-540): 7.89e-44: 175: 13.03
+	Hs
		449842 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		SRRM2_HUMAN (2-858): 2.43e-23: 109: 14.55
+	Hs
		996965 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		SRRM2_HUMAN (2-858): 2.43e-23: 109: 14.55
+	Hs
		449779 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		TITIN_HUMAN (105-799): 3.29e-11: 70: 7.20
+	Hs
		617319 SP100_HUMAN (25-178): 1.23e-34: 131: 87.66		NIPBL_HUMAN (138-674): 7.25e-11: 68.9: 13.20
+	Hs
		996715 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		NIPBL_HUMAN (138-674): 7.25e-11: 68.9: 13.20
+	Hs
		818155 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		NIPBL_HUMAN (138-674): 7.25e-11: 68.9: 13.20