HitPredict

Interactor 1: HSP73 (P09435)
Heat shock protein SSA3
Gene: SSA3

Interactor 2: SIS1 (P25294)
Protein SIS1
Gene: SIS1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	17892321, 33326013
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006457 - protein folding GO:0051082 - unfolded protein binding GO:0051085 - chaperone cofactor-dependent protein refolding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 649 Sc			1 352
+	Hs
		681341 HS71L_HUMAN (2-649): 0: 958: 70.06		DNJA1_HUMAN (1-352): 2.53e-121: 357: 28.93
+	Hs
		243312 HS71L_HUMAN (2-649): 0: 958: 70.06		DNJA2_HUMAN (2-352): 5.07e-121: 356: 28.09
+	Hs
		564015 HSP76_HUMAN (4-649): 0: 950: 70.43		DNJA1_HUMAN (1-352): 2.53e-121: 357: 28.93
+	Hs
		243284 HSP76_HUMAN (4-649): 0: 950: 70.43		DNJA2_HUMAN (2-352): 5.07e-121: 356: 28.09
+	Hs
		503527 HSP7C_HUMAN (2-649): 0: 946: 72.53		DNJA1_HUMAN (1-352): 2.53e-121: 357: 28.93
+	Hs
		243275 HSP7C_HUMAN (2-649): 0: 946: 72.53		DNJA2_HUMAN (2-352): 5.07e-121: 356: 28.09
+	Hs
		564136 HSP76_HUMAN (4-649): 0: 950: 70.43		DNJA4_HUMAN (1-352): 3.62e-119: 351: 28.65
+	Hs
		279280 HS71L_HUMAN (2-649): 0: 958: 70.06		DNJB5_HUMAN (5-352): 6.21e-116: 341: 33.52
+	Hs
		279274 HSP76_HUMAN (4-649): 0: 950: 70.43		DNJB5_HUMAN (5-352): 6.21e-116: 341: 33.52
+	Hs
		714088 HS71L_HUMAN (2-649): 0: 958: 70.06		DNJB4_HUMAN (5-352): 1.08e-112: 332: 34.08
+	Hs
		279272 HSP7C_HUMAN (2-649): 0: 946: 72.53		DNJB5_HUMAN (5-352): 6.21e-116: 341: 33.52
+	Hs
		564203 HSP76_HUMAN (4-649): 0: 950: 70.43		DNJB4_HUMAN (5-352): 1.08e-112: 332: 34.08
+	Hs
		636256 HS71L_HUMAN (2-649): 0: 958: 70.06		DNJB1_HUMAN (5-352): 5.62e-109: 323: 34.09
+	Sc
		449929 HSP73_YEAST (1-649): 0: 948: 100.00		MAS5_YEAST (1-352): 1.41e-111: 332: 28.13
+	Hs
		504901 HSP7C_HUMAN (2-649): 0: 946: 72.53		DNJB4_HUMAN (5-352): 1.08e-112: 332: 34.08
+	Sc
		493305 HSP72_YEAST (1-649): 0: 941: 78.89		MAS5_YEAST (1-352): 1.41e-111: 332: 28.13
+	Hs
		564008 HSP76_HUMAN (4-649): 0: 950: 70.43		DNJB1_HUMAN (5-352): 5.62e-109: 323: 34.09
+	Hs
		503463 HSP7C_HUMAN (2-649): 0: 946: 72.53		DNJB1_HUMAN (5-352): 5.62e-109: 323: 34.09
+	Sc
		493267 HSP72_YEAST (1-649): 0: 941: 78.89		SIS1_YEAST (1-352): 6.96e-105: 313: 100.00
+	Sc
		490423 HSP71_YEAST (1-649): 0: 939: 79.35		SIS1_YEAST (1-352): 6.96e-105: 313: 100.00