HitPredict

Interactor 1: C1TM (P09440)
C-1-tetrahydrofolate synthase, mitochondrial (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]
Gene: MIS1

Interactor 2: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31399574, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 975 Sc			1 705
+	Hs
		437841 C1TC_HUMAN (32-975): 0: 1529: 55.64		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Hs
		431474 C1TC_HUMAN (32-975): 0: 1529: 55.64		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Sc
		365613 C1TM_YEAST (13-975): 0: 1531: 100.00		HSP82_YEAST (1-705): 0: 968: 95.63
+	Sc
		423507 C1TC_YEAST (36-975): 0: 1439: 71.10		HSC82_YEAST (1-705): 0: 977: 100.00
+	Sc
		365570 C1TC_YEAST (36-975): 0: 1439: 71.10		HSP82_YEAST (1-705): 0: 968: 95.63
+	Sc
		544265 MTD1_YEAST (42-329): 3.11e-62: 216: 24.17		HSC82_YEAST (1-705): 0: 977: 100.00
+	Sc
		366753 MTD1_YEAST (42-329): 3.11e-62: 216: 24.17		HSP82_YEAST (1-705): 0: 968: 95.63