HitPredict

Interactor 1: GNAO (P09471)
Guanine nucleotide-binding protein G(o) subunit alpha
Gene: GNAO1

Interactor 2: RGS4 (P49798)
Regulator of G-protein signaling 4 (RGP4) (RGS4)
Gene: RGS4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	10727532, 9660808
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 354 Hs			1 205
+	Rn
		834945 GNAO_RAT (1-354): 1.95e-174: 490: 98.59		RGS4_RAT (1-205): 1.71e-83: 248: 97.07
+	Hs
		391358 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		RGS4_HUMAN (1-205): 8.99e-84: 248: 100.00
+	Rn
		500350 GNAI1_RAT (1-354): 2.09e-170: 480: 72.11		RGS4_RAT (1-205): 1.71e-83: 248: 97.07
+	Hs
		182443 GNAO_HUMAN (1-354): 3.01e-176: 494: 100.00		RGS5_HUMAN (1-179): 1.24e-70: 214: 52.49
+	Hs
		180653 GNAO_HUMAN (1-354): 3.01e-176: 494: 100.00		RGS16_HUMAN (1-177): 2.47e-69: 211: 49.44
+	Mm
		579645 GNAO_MOUSE (1-354): 3.97e-174: 489: 98.02		RGS16_MOUSE (1-198): 4.64e-71: 216: 44.00
+	Hs
		391357 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		RGS3_HUMAN (16-184): 3.99e-65: 218: 52.66
+	Hs
		182439 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		RGS5_HUMAN (1-179): 1.24e-70: 214: 52.49
+	Hs
		277782 GNAO_HUMAN (1-354): 3.01e-176: 494: 100.00		RGS9_HUMAN (31-194): 2.97e-59: 198: 30.72
+	Hs
		180650 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		RGS16_HUMAN (1-177): 2.47e-69: 211: 49.44
+	Hs
		283160 GNAO_HUMAN (1-354): 3.01e-176: 494: 100.00		RGS20_HUMAN (26-185): 4.74e-61: 196: 38.65
+	Hs
		450988 GNAO_HUMAN (1-354): 3.01e-176: 494: 100.00		RGS19_HUMAN (27-188): 2.18e-60: 189: 36.42
+	Hs
		391473 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		RGS18_HUMAN (15-200): 5.06e-63: 197: 43.55
+	Hs
		283156 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		RGS20_HUMAN (26-185): 4.74e-61: 196: 38.65
+	Hs
		391356 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		RGS19_HUMAN (27-188): 2.18e-60: 189: 36.42
+	Mm
		579646 GNAO_MOUSE (1-354): 3.97e-174: 489: 98.02		RGS14_MOUSE (18-185): 2.47e-51: 175: 32.35
+	Hs
		158580 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		RGS13_HUMAN (32-186): 1.91e-58: 182: 41.29
+	Hs
		158597 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		RGS12_HUMAN (44-178): 3.37e-52: 181: 38.69
+	Hs
		207505 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		RGS14_HUMAN (18-198): 1.03e-53: 181: 30.98
+	Ce
		711280 GNAO_CAEEL (1-354): 1.94e-170: 480: 82.20		RGS1_CAEEL (37-205): 9.92e-55: 174: 40.57