HitPredict

Interactor 1: GNAO (P09471)
Guanine nucleotide-binding protein G(o) subunit alpha
Gene: GNAO1

Interactor 2: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	32505358, 35271311
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	G-alpha~WD40
Common GO terms	GO:0003924 - GTPase activity GO:0005737 - cytoplasm GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 354 Hs			1 340
+	Mm
		579642 GNAO_MOUSE (1-354): 3.97e-174: 489: 98.02		GBB1_MOUSE (1-340): 7.02e-105: 312: 100.00
+	Ce
		567431 GNAO_CAEEL (1-354): 1.94e-170: 480: 82.20		GBB1_CAEEL (1-340): 7.67e-107: 317: 85.88
+	Hs
		391374 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		921512 GNAI1_HUMAN (1-354): 1.98e-170: 480: 72.11		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		391373 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		391465 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Bt
		920924 GNAI1_BOVIN (1-354): 1.98e-170: 480: 72.11		GBB1_BOVIN (1-340): 7.02e-105: 312: 100.00
+	Hs
		920929 GNAI1_HUMAN (1-354): 1.98e-170: 480: 72.11		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		926713 GNAI1_HUMAN (1-354): 1.98e-170: 480: 72.11		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		391321 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Hs
		444706 GNAI3_HUMAN (1-354): 9.79e-168: 473: 71.27		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		444705 GNAI3_HUMAN (1-354): 9.79e-168: 473: 71.27		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		444791 GNAI3_HUMAN (1-354): 9.79e-168: 473: 71.27		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		444660 GNAI3_HUMAN (1-354): 9.79e-168: 473: 71.27		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Dm
		558469 GNAO_DROME (1-354): 8.23e-166: 468: 82.20		GBB1_DROME (1-340): 1.54e-103: 309: 83.53
+	Hs
		920942 GNA12_HUMAN (3-353): 1.39e-160: 456: 41.08		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		560863 GNAQ_HUMAN (1-353): 4.44e-161: 456: 50.85		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Hs
		560875 GNA12_HUMAN (3-353): 1.39e-160: 456: 41.08		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Hs
		391370 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		WDR5_HUMAN (4-211): 4.16e-56: 187: 20.93
+	Hs
		444702 GNAI3_HUMAN (1-354): 9.79e-168: 473: 71.27		WDR5_HUMAN (4-211): 4.16e-56: 187: 20.93