HitPredict

Interactor 1: GNAO (P09471)
Guanine nucleotide-binding protein G(o) subunit alpha
Gene: GNAO1

Interactor 2: GBG3 (P63215)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Gene: GNG3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0030425 - dendrite GO:0044297 - cell body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 354 Hs			1 75
+	Hs
		450995 GNAO_HUMAN (1-354): 3.01e-176: 494: 100.00		GBG2_HUMAN (5-75): 2.64e-28: 98.2: 76.06
+	Mm
		579644 GNAO_MOUSE (1-354): 3.97e-174: 489: 98.02		GBG2_MOUSE (5-75): 2.64e-28: 98.2: 76.06
+	Hs
		451049 GNAO_HUMAN (1-354): 3.01e-176: 494: 100.00		GBG8_HUMAN (7-75): 6.35e-25: 89.3: 56.52
+	Hs
		391377 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		GBG3_HUMAN (1-75): 2.04e-30: 103: 100.00
+	Hs
		926667 GNAI1_HUMAN (1-354): 1.98e-170: 480: 72.11		GBG3_HUMAN (1-75): 2.04e-30: 103: 100.00
+	Hs
		391359 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		GBG4_HUMAN (1-75): 4.61e-29: 100: 69.33
+	Hs
		837675 GNAI1_HUMAN (1-354): 1.98e-170: 480: 72.11		GBG4_HUMAN (1-75): 4.61e-29: 100: 69.33
+	Hs
		391364 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		GBG2_HUMAN (5-75): 2.64e-28: 98.2: 76.06
+	Hs
		887099 GNAI1_HUMAN (1-354): 1.98e-170: 480: 72.11		GBG2_HUMAN (5-75): 2.64e-28: 98.2: 76.06
+	Hs
		450990 GNAO_HUMAN (1-354): 3.01e-176: 494: 100.00		GBG10_HUMAN (7-75): 2.48e-22: 82.8: 50.73
+	Hs
		444694 GNAI3_HUMAN (1-354): 9.79e-168: 473: 71.27		GBG4_HUMAN (1-75): 4.61e-29: 100: 69.33
+	Hs
		229233 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		GBG7_HUMAN (7-75): 5.89e-25: 89.3: 60.87
+	Hs
		229239 GNAI1_HUMAN (1-354): 1.98e-170: 480: 72.11		GBG7_HUMAN (7-75): 5.89e-25: 89.3: 60.87
+	Hs
		391482 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		GBG8_HUMAN (7-75): 6.35e-25: 89.3: 56.52
+	Hs
		926724 GNAI1_HUMAN (1-354): 1.98e-170: 480: 72.11		GBG8_HUMAN (7-75): 6.35e-25: 89.3: 56.52
+	Hs
		391360 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		GBG10_HUMAN (7-75): 2.48e-22: 82.8: 50.73
+	Hs
		837689 GNAI1_HUMAN (1-354): 1.98e-170: 480: 72.11		GBG10_HUMAN (7-75): 2.48e-22: 82.8: 50.73
+	Hs
		229234 GNAI3_HUMAN (1-354): 9.79e-168: 473: 71.27		GBG7_HUMAN (7-75): 5.89e-25: 89.3: 60.87
+	Hs
		391378 GNAI2_HUMAN (1-354): 1.16e-170: 480: 69.30		GBG5_HUMAN (7-75): 1.42e-21: 80.9: 46.38
+	Hs
		926668 GNAI1_HUMAN (1-354): 1.98e-170: 480: 72.11		GBG5_HUMAN (7-75): 1.42e-21: 80.9: 46.38