HitPredict

Interactor 1: TPM1 (P09493)
Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)
Gene: TPM1

Interactor 2: MD1L1 (Q9Y6D9)
Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181)
Gene: MAD1L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.757

Property	Details
Experiments	32296183, 25416956, 26186194, 25910212, 28514442, 26871637, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, two hybrid bait and prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 284 Hs			1 718
+	Hs
		419092 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		MD1L1_HUMAN (1-718): 9.25e-62: 221: 100.00
+	Hs
		1138404 Q5VU62_HUMAN (127-284): 3.37e-44: 149: 90.51		MD1L1_HUMAN (1-718): 9.25e-62: 221: 100.00
+	Hs
		1137871 MRCKA_HUMAN (1-282): 1.08e-31: 126: 17.67		MRCKA_HUMAN (164-708): 6.22e-43: 170: 17.69
+	Dm
		419108 TPM1_DROME (1-281): 3.07e-56: 186: 44.78		MYSN_DROME (131-716): 5.22e-24: 110: 14.52
+	Hs
		451201 TPM1_HUMAN (1-284): 2.35e-44: 153: 100.00		MYH9_HUMAN (286-715): 8.08e-18: 90.5: 13.86
+	Hs
		418895 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		MYH9_HUMAN (286-715): 8.08e-18: 90.5: 13.86
+	Hs
		434354 TPM2_HUMAN (1-284): 1.39e-38: 138: 85.56		MYH9_HUMAN (286-715): 8.08e-18: 90.5: 13.86
+	Hs
		148289 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		CTRO_HUMAN (54-632): 5.17e-13: 75: 15.98
+	Hs
		451288 TPM1_HUMAN (1-284): 2.35e-44: 153: 100.00		DLG5_HUMAN (125-628): 3.83e-12: 72.3: 15.98
+	Mm
		358674 LAMB1_MOUSE (1-253): 7.27e-39: 146: 19.84		LAMC1_MOUSE (43-530): 3.84e-14: 78.8: 16.18
+	Hs
		110796 H7BYY1_HUMAN (41-284): 8.14e-35: 127: 70.49		MYH9_HUMAN (286-715): 8.08e-18: 90.5: 13.86
+	Hs
		451293 TPM1_HUMAN (1-284): 2.35e-44: 153: 100.00		MY18A_HUMAN (44-521): 2.6e-09: 63: 15.87
+	Hs
		419011 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		MY18A_HUMAN (44-521): 2.6e-09: 63: 15.87
+	Hs
		724765 TPM4_HUMAN (42-284): 3.76e-33: 123: 68.72		MYH9_HUMAN (286-715): 8.08e-18: 90.5: 13.86
+	Hs
		434415 TPM2_HUMAN (1-284): 1.39e-38: 138: 85.56		MY18A_HUMAN (44-521): 2.6e-09: 63: 15.87
+	Hs
		148661 TPM4_HUMAN (42-284): 3.76e-33: 123: 68.72		CTRO_HUMAN (54-632): 5.17e-13: 75: 15.98
+	Rn
		222476 MRCKB_RAT (1-283): 1.5e-32: 128: 19.60		MRCKA_RAT (1-359): 5.67e-11: 68.3: 11.92
+	Rn
		1186812 MRCKB_RAT (1-283): 1.5e-32: 128: 19.60		MRCKB_RAT (1-400): 2.49e-09: 63.1: 13.22
+	Hs
		110802 H7BYY1_HUMAN (41-284): 8.14e-35: 127: 70.49		MY18A_HUMAN (44-521): 2.6e-09: 63: 15.87
+	Hs
		1137917 MRCKA_HUMAN (1-282): 1.08e-31: 126: 17.67		MRCKB_HUMAN (1-389): 1.46e-09: 63.8: 11.96