HitPredict

Interactor 1: INHBB (P09529)
Inhibin beta B chain (Activin beta-B chain)
Gene: INHBB

Interactor 2: ACV1B (P36896)
Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
Gene: ACVR1B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9202237
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	GO:0032924 - activin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 407 Hs			1 505
+	Mm
		982854 INHBA_MOUSE (43-407): 2.67e-106: 321: 42.26		ACV1B_MOUSE (1-505): 7.72e-154: 449: 98.22
+	Hs
		439882 INHBA_HUMAN (43-407): 3.12e-104: 316: 41.57		ACV1B_HUMAN (1-505): 2.52e-154: 451: 100.00
+	Hs
		451817 INHBB_HUMAN (1-407): 4.22e-149: 430: 100.00		AVR2A_HUMAN (51-503): 1.84e-108: 333: 30.37
+	Hs
		451820 INHBB_HUMAN (1-407): 4.22e-149: 430: 100.00		AVR2B_HUMAN (51-502): 1.1e-107: 331: 30.87
+	Hs
		520071 BMP2_HUMAN (49-406): 4.94e-109: 327: 23.70		BMR1A_HUMAN (19-505): 4.06e-145: 428: 49.29
+	Hs
		122280 BMP2_HUMAN (49-406): 4.94e-109: 327: 23.70		BMR1B_HUMAN (19-505): 8.25e-143: 421: 49.80
+	Hs
		451821 INHBB_HUMAN (1-407): 4.22e-149: 430: 100.00		BMPR2_HUMAN (1-497): 1.81e-95: 313: 28.68
+	Hs
		439885 INHBA_HUMAN (43-407): 3.12e-104: 316: 41.57		ACVR1_HUMAN (12-502): 2.83e-137: 407: 48.20
+	Hs
		122282 BMP7_HUMAN (67-406): 4.61e-98: 301: 21.52		BMR1B_HUMAN (19-505): 8.25e-143: 421: 49.80
+	Hs
		439883 INHBA_HUMAN (43-407): 3.12e-104: 316: 41.57		ACVL1_HUMAN (13-502): 5.72e-134: 398: 46.96
+	Hs
		520070 BMP2_HUMAN (49-406): 4.94e-109: 327: 23.70		AVR2A_HUMAN (51-503): 1.84e-108: 333: 30.37
+	Hs
		520077 BMP2_HUMAN (49-406): 4.94e-109: 327: 23.70		AVR2B_HUMAN (51-502): 1.1e-107: 331: 30.87
+	Mm
		646092 INHBA_MOUSE (43-407): 2.67e-106: 321: 42.26		AVR2B_MOUSE (51-502): 3.35e-109: 336: 30.59
+	Mm
		646088 INHBA_MOUSE (43-407): 2.67e-106: 321: 42.26		AVR2A_MOUSE (51-503): 1.57e-108: 334: 30.37
+	Hs
		439881 INHBA_HUMAN (43-407): 3.12e-104: 316: 41.57		AVR2A_HUMAN (51-503): 1.84e-108: 333: 30.37
+	Hs
		439886 INHBA_HUMAN (43-407): 3.12e-104: 316: 41.57		AVR2B_HUMAN (51-502): 1.1e-107: 331: 30.87
+	Hs
		59851 A4D1W7_HUMAN (43-407): 3.12e-104: 316: 41.57		AVR2B_HUMAN (51-502): 1.1e-107: 331: 30.87
+	Hs
		520078 BMP2_HUMAN (49-406): 4.94e-109: 327: 23.70		BMPR2_HUMAN (1-497): 1.81e-95: 313: 28.68
+	Hs
		574181 BMP7_HUMAN (67-406): 4.61e-98: 301: 21.52		AVR2A_HUMAN (51-503): 1.84e-108: 333: 30.37
+	Hs
		439887 INHBA_HUMAN (43-407): 3.12e-104: 316: 41.57		BMPR2_HUMAN (1-497): 1.81e-95: 313: 28.68