HitPredict

Interactor 1: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Interactor 2: CBLB (Q13191)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27048651
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1106 Hs			1 982
+	Hs
		499262 KIT_HUMAN (3-1003): 0: 601: 29.99		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Mm
		404008 PGFRB_MOUSE (1-1106): 0: 801: 85.44		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		452353 PGFRB_HUMAN (1-1106): 0: 795: 100.00		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		557035 PGFRA_HUMAN (3-1106): 0: 716: 42.48		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		403532 KIT_MOUSE (24-1004): 0: 603: 31.01		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		499234 KIT_HUMAN (3-1003): 0: 601: 29.99		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		610268 FLT3_HUMAN (21-1008): 7e-168: 522: 26.73		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		607956 FGFR4_HUMAN (200-413): 5.32e-14: 78.7: 17.73		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Hs
		601457 FGFR2_HUMAN (9-326): 2.34e-58: 218: 11.51		CBL_HUMAN (25-976): 0: 675: 47.10
+	Dm
		112207 M9MRE1_DROME (32-503): 7e-43: 173: 16.67		O46034_DROME (27-434): 0: 718: 71.39
+	Hs
		572586 VGFR1_HUMAN (33-627): 2.19e-51: 200: 18.47		CBL_HUMAN (25-976): 0: 675: 47.10
+	Rn
		88773 VGFR1_RAT (3-613): 1.51e-58: 222: 20.86		D3ZV15_RAT (25-931): 0: 647: 48.11
+	Mm
		610553 VGFR1_MOUSE (64-792): 2.64e-38: 158: 9.98		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		607879 FGFR4_HUMAN (200-413): 5.32e-14: 78.7: 17.73		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		608187 FGFR4_HUMAN (200-413): 5.32e-14: 78.7: 17.73		CBLC_HUMAN (29-497): 0: 585: 44.65
+	Hs
		1081569 NTRK3_HUMAN (65-966): 1.49e-133: 427: 16.58		NSD1_HUMAN (373-939): 6.49e-27: 121: 13.23
+	Hs
		508077 FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44		MICA3_HUMAN (397-980): 2.53e-15: 83.1: 12.89
+	Hs
		203204 FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44		SYNJ1_HUMAN (356-779): 6.17e-15: 82: 6.35
+	Hs
		729301 VGFR3_HUMAN (32-529): 2.63e-47: 187: 19.38		MCAF1_HUMAN (440-932): 1.82e-23: 109: 13.37
+	Rn
		94375 FGFR1_RAT (16-326): 1.82e-20: 99.6: 13.43		F1M9G7_RAT (411-858): 1.97e-09: 64.2: 9.91