HitPredict

Interactor 1: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Interactor 2: PTPRO (Q16827)
Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2)
Gene: PTPRO

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	fn3~ig, Ig_3~fn3, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0016324 - apical plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1106 Hs			1 1216
+	Hs
		499270 KIT_HUMAN (3-1003): 0: 601: 29.99		PTPRO_HUMAN (1-1216): 0: 2236: 100.00
+	Hs
		1031135 PTK7_HUMAN (28-630): 9.12e-42: 168: 12.58		PTPRO_HUMAN (1-1216): 0: 2236: 100.00
+	Hs
		452355 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRB_HUMAN (912-1214): 2.71e-123: 422: 47.91
+	Hs
		452405 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRJ_HUMAN (911-1214): 8.14e-117: 396: 44.48
+	Hs
		452411 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRS_HUMAN (918-1196): 2.2e-100: 354: 37.15
+	Hs
		452356 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRE_HUMAN (918-1196): 1.2e-93: 318: 32.88
+	Hs
		441166 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRC_HUMAN (918-1204): 1.51e-71: 264: 28.26
+	Hs
		452426 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRK_HUMAN (917-1199): 1.9e-57: 220: 29.20
+	Hs
		452357 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRG_HUMAN (937-1200): 8.02e-53: 205: 29.09
+	Hs
		499261 KIT_HUMAN (3-1003): 0: 601: 29.99		PTPRJ_HUMAN (911-1214): 8.14e-117: 396: 44.48
+	Hs
		499281 KIT_HUMAN (3-1003): 0: 601: 29.99		PTPRU_HUMAN (918-1200): 4.38e-58: 222: 29.63
+	Hs
		1031989 NTRK3_HUMAN (65-966): 1.49e-133: 427: 16.58		PTPRS_HUMAN (918-1196): 2.2e-100: 354: 37.15
+	Rn
		976067 NTRK3_RAT (65-966): 4.84e-137: 437: 16.32		PTPRS_RAT (918-1196): 1.72e-96: 342: 36.81
+	Hs
		572587 VGFR1_HUMAN (33-627): 2.19e-51: 200: 18.47		PTPRB_HUMAN (912-1214): 2.71e-123: 422: 47.91
+	Hs
		507980 FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44		PTPRS_HUMAN (918-1196): 2.2e-100: 354: 37.15
+	Hs
		572628 VGFR1_HUMAN (33-627): 2.19e-51: 200: 18.47		PTPRJ_HUMAN (911-1214): 8.14e-117: 396: 44.48
+	Hs
		729647 VGFR2_HUMAN (10-197): 4.73e-11: 69.5: 11.31		PTPRJ_HUMAN (911-1214): 8.14e-117: 396: 44.48
+	Hs
		719338 PTK7_HUMAN (28-630): 9.12e-42: 168: 12.58		PTN7_HUMAN (958-1194): 3.98e-54: 195: 43.33