HitPredict

Interactor 1: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Interactor 2: VAV3 (Q9UKW4)
Guanine nucleotide exchange factor VAV3 (VAV-3)
Gene: VAV3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10938113
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1106 Hs			1 847
+	Hs
		452342 PGFRB_HUMAN (1-1106): 0: 795: 100.00		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		452375 PGFRB_HUMAN (1-1106): 0: 795: 100.00		VAV2_HUMAN (1-846): 0: 574: 50.00
+	Hs
		499291 KIT_HUMAN (3-1003): 0: 601: 29.99		VAV3_HUMAN (1-847): 0: 663: 100.00
+	Mm
		403536 KIT_MOUSE (24-1004): 0: 603: 31.01		VAV_MOUSE (1-846): 0: 600: 57.90
+	Hs
		452448 PGFRB_HUMAN (1-1106): 0: 795: 100.00		FGD6_HUMAN (86-611): 2.71e-73: 264: 15.69
+	Hs
		548695 MERTK_HUMAN (120-967): 1.8e-135: 437: 16.54		VAV_HUMAN (1-846): 0: 609: 57.31
+	Ce
		1014309 EGL15_CAEEL (11-1064): 1.41e-153: 486: 16.68		VAV_CAEEL (2-847): 1.48e-120: 390: 22.17
+	Hs
		452348 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Mm
		404013 PGFRB_MOUSE (1-1106): 0: 801: 85.44		GRB2_MOUSE (793-844): 2.65e-11: 65.9: 40.39
+	Hs
		452385 PGFRB_HUMAN (1-1106): 0: 795: 100.00		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		557029 PGFRA_HUMAN (3-1106): 0: 716: 42.48		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		557088 PGFRA_HUMAN (3-1106): 0: 716: 42.48		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		499264 KIT_HUMAN (3-1003): 0: 601: 29.99		GRAP_HUMAN (613-844): 1.55e-21: 95.9: 27.47
+	Hs
		499228 KIT_HUMAN (3-1003): 0: 601: 29.99		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		499230 KIT_HUMAN (3-1003): 0: 601: 29.99		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Mm
		403541 KIT_MOUSE (24-1004): 0: 603: 31.01		GRB2_MOUSE (793-844): 2.65e-11: 65.9: 40.39
+	Hs
		499253 KIT_HUMAN (3-1003): 0: 601: 29.99		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		738192 FLT3_HUMAN (21-1008): 7e-168: 522: 26.73		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Mm
		1141452 MERTK_MOUSE (125-972): 1.33e-135: 437: 16.13		PLCG2_MOUSE (661-845): 2.07e-14: 79.7: 30.69
+	Hs
		924527 MERTK_HUMAN (120-967): 1.8e-135: 437: 16.54		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39