HitPredict

Interactor 1: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Interactor 2: PTN22 (Q9Y2R2)
Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)
Gene: PTPN22

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1106 Hs			1 807
+	Hs
		452398 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTN12_HUMAN (1-696): 0: 723: 36.81
+	Hs
		499258 KIT_HUMAN (3-1003): 0: 601: 29.99		PTN12_HUMAN (1-696): 0: 723: 36.81
+	Hs
		452363 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTN6_HUMAN (2-344): 6.3e-137: 420: 32.30
+	Hs
		452355 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRB_HUMAN (18-314): 2.09e-117: 393: 31.19
+	Hs
		452411 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRS_HUMAN (13-292): 1.12e-105: 359: 35.66
+	Hs
		452356 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRE_HUMAN (11-290): 2.43e-98: 322: 32.53
+	Hs
		499236 KIT_HUMAN (3-1003): 0: 601: 29.99		PTN6_HUMAN (2-344): 6.3e-137: 420: 32.30
+	Hs
		452426 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRK_HUMAN (20-292): 9.08e-61: 225: 30.96
+	Hs
		452357 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRG_HUMAN (30-294): 3.35e-51: 196: 25.54
+	Hs
		452405 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRJ_HUMAN (15-295): 2.81e-48: 187: 38.10
+	Hs
		452433 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRO_HUMAN (45-299): 3.56e-43: 171: 38.22
+	Hs
		452399 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTN11_HUMAN (287-497): 2.12e-12: 72.5: 14.09
+	Hs
		441166 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRC_HUMAN (61-462): 5.14e-11: 68.6: 9.24
+	Hs
		499281 KIT_HUMAN (3-1003): 0: 601: 29.99		PTPRU_HUMAN (20-295): 8.8e-60: 223: 25.80
+	Hs
		557099 PGFRA_HUMAN (3-1106): 0: 716: 42.48		PTN11_HUMAN (287-497): 2.12e-12: 72.5: 14.09
+	Hs
		499261 KIT_HUMAN (3-1003): 0: 601: 29.99		PTPRJ_HUMAN (15-295): 2.81e-48: 187: 38.10
+	Rn
		976067 NTRK3_RAT (65-966): 4.84e-137: 437: 16.32		PTPRS_RAT (13-292): 5.3e-102: 348: 34.97
+	Hs
		499270 KIT_HUMAN (3-1003): 0: 601: 29.99		PTPRO_HUMAN (45-299): 3.56e-43: 171: 38.22
+	Hs
		499259 KIT_HUMAN (3-1003): 0: 601: 29.99		PTN11_HUMAN (287-497): 2.12e-12: 72.5: 14.09
+	Hs
		738197 FLT3_HUMAN (21-1008): 7e-168: 522: 26.73		PTN11_HUMAN (287-497): 2.12e-12: 72.5: 14.09