HitPredict

Interactor 1: DLDH (P09622)
Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)
Gene: DLD

Interactor 2: ODO1 (Q02218)
2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase)
Gene: OGDH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	9727038, 26186194, 28514442, 33961781
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0045252 - oxoglutarate dehydrogenase complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 1023
+	Hs
		452914 DLDH_HUMAN (1-509): 0: 543: 100.00		OGDHL_HUMAN (1-1020): 0: 1495: 75.78
+	Sc
		452953 DLDH_YEAST (10-508): 4.36e-154: 450: 52.77		ODO1_YEAST (1-1015): 0: 1270: 44.88
+	Hs
		452856 DLDH_HUMAN (1-509): 0: 543: 100.00		DHTK1_HUMAN (98-1014): 0: 1086: 37.94
+	Ec
		465060 DLDH_ECOLI (36-494): 1.56e-129: 386: 42.05		ODO1_ECOLI (48-1017): 0: 1124: 38.22
+	Hs
		440305 DLDH_HUMAN (1-509): 0: 543: 100.00		ODPA_HUMAN (237-598): 3.05e-93: 303: 16.89
+	At
		1210838 DLDH1_ARATH (1-508): 2.26e-166: 481: 54.92		ODPA2_ARATH (245-607): 3.18e-98: 317: 18.33
+	Sc
		452947 DLDH_YEAST (10-508): 4.36e-154: 450: 52.77		ODPA_YEAST (244-603): 9.5e-99: 319: 18.16