HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	32812023, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003697 - single-stranded DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm and 1 others more... GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 372 Hs			1 758
+	Hs
		201653 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		161944 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496306 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496607 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		582022 ROA3_RAT (7-202): 6.13e-55: 186: 85.71		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94248 ROA3_RAT (7-202): 6.13e-55: 186: 85.71		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Mm
		498127 ROA0_MOUSE (9-186): 4.93e-59: 195: 59.55		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Hs
		497496 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496937 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496995 HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497424 MSI2H_HUMAN (2-91): 6.69e-16: 79.8: 35.56		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496957 PABP4_HUMAN (102-190): 3.52e-15: 79: 15.56		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496405 TIA1_HUMAN (99-193): 5.41e-09: 59.4: 17.71		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		64991 ROA2_RAT (3-106): 1.19e-19: 91: 28.85		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Rn
		64993 ROA2_RAT (3-106): 1.19e-19: 91: 28.85		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Mm
		497953 TIA1_MOUSE (99-193): 5.17e-09: 59.4: 17.71		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Hs
		654044 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56
+	Hs
		1056955 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57