HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: ERF3A (P15170)
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog)
Gene: GSPT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 372 Hs			1 499
+	Hs
		161954 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		ERF3A_HUMAN (1-499): 0: 567: 100.00
+	Hs
		453270 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		EF1A1_HUMAN (70-498): 1.24e-175: 503: 38.29
+	Hs
		545899 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		ERF3A_HUMAN (1-499): 0: 567: 100.00
+	Hs
		1020291 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		ERF3B_HUMAN (1-499): 0: 558: 93.79
+	Hs
		545846 PABP4_HUMAN (102-190): 3.52e-15: 79: 15.56		ERF3A_HUMAN (1-499): 0: 567: 100.00
+	Sc
		367579 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		EF1A_YEAST (70-494): 1.07e-172: 495: 37.27
+	Sc
		376568 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		ERF3_YEAST (72-494): 7.68e-168: 491: 57.51
+	Hs
		1031386 PABP4_HUMAN (102-190): 3.52e-15: 79: 15.56		ERF3B_HUMAN (1-499): 0: 558: 93.79
+	Zm
		9835 A0A1D6EZQ5_MAIZE (7-367): 1.68e-16: 82.5: 22.99		O50018_MAIZE (70-499): 1.75e-172: 495: 38.57