HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22446626
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 494
+	Hs
		453308 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42
+	Hs
		453328 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50
+	Hs
		453327 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53
+	Mm
		825794 ROA1_MOUSE (1-302): 7.42e-58: 192: 86.09		SRSF9_MOUSE (3-216): 4.58e-52: 177: 36.53
+	Sc
		376750 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		NOP4_YEAST (1-492): 1.19e-52: 190: 11.82
+	Hs
		453107 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		161948 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		516358 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		516424 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		992743 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42
+	Cn
		111495 J9VUR9_CRYNH (13-186): 2.19e-31: 127: 22.29		J9VJ75_CRYNH (3-179): 9.05e-43: 161: 30.85
+	Hs
		453331 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78
+	Hs
		516689 PABP3_HUMAN (6-193): 6.86e-35: 137: 17.90		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		201707 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		RBM4B_HUMAN (3-104): 4.68e-11: 66.1: 23.08
+	Hs
		516663 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		162035 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78
+	Sc
		376649 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		GBP2_YEAST (4-201): 2.69e-25: 109: 20.19
+	Hs
		516484 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Sc
		376562 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		PABP_YEAST (72-188): 2.61e-10: 64.6: 14.75
+	Hs
		474019 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		PAB4L_HUMAN (100-185): 1.44e-10: 65: 19.78