HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: PABP2 (Q86U42)
Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1)
Gene: PABPN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	12945950
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:1990904 - ribonucleoprotein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 306
+	Hs
		62520 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		RFOX3_HUMAN (75-301): 1.74e-33: 126: 17.80
+	Hs
		453291 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		RBM3_HUMAN (167-304): 1.15e-32: 119: 22.45
+	Hs
		453350 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		CIRBP_HUMAN (167-306): 3.86e-32: 119: 19.15
+	Hs
		609811 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		RBM3_HUMAN (167-304): 1.15e-32: 119: 22.45
+	Hs
		851999 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		NCBP2_HUMAN (142-298): 5.3e-33: 120: 15.82
+	Hs
		453107 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		453533 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		DAZP1_HUMAN (163-285): 3.6e-21: 94.6: 21.14
+	Hs
		453331 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP4_HUMAN (163-260): 1.04e-20: 94.2: 17.17
+	Hs
		161948 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		516358 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		516424 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		162035 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP4_HUMAN (163-260): 1.04e-20: 94.2: 17.17
+	Sc
		376818 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		SGN1_YEAST (116-301): 3.31e-32: 121: 25.00
+	Sp
		145447 PABP_SCHPO (2-189): 7.49e-37: 142: 21.05		PAB2_SCHPO (107-255): 3.12e-34: 124: 48.32
+	Hs
		853967 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		NCBP2_HUMAN (142-298): 5.3e-33: 120: 15.82
+	Sc
		376562 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		PABP_YEAST (143-260): 3.27e-19: 89.6: 20.17
+	Hs
		516689 PABP3_HUMAN (6-193): 6.86e-35: 137: 17.90		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		516663 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Sc
		376785 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		HRB1_YEAST (153-268): 1.5e-16: 81.4: 29.51
+	Sc
		376694 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		PUB1_YEAST (165-255): 5.29e-09: 58.8: 18.48