HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: TNPO1 (Q92973)
Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)
Gene: TNPO1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.812

Property	Details
Experiments	35271311, 17435768
Identification Methods	affinity chromatography technology, isothermal titration calorimetry, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	HEAT_EZ~HnRNPA1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 372 Hs			1 898
+	Hs
		609984 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		TNPO1_HUMAN (1-898): 0: 663: 100.00
+	Hs
		852123 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		TNPO1_HUMAN (1-898): 0: 663: 100.00
+	Hs
		155517 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		TNPO2_HUMAN (11-898): 0: 613: 84.30
+	Hs
		1048166 HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00		TNPO1_HUMAN (1-898): 0: 663: 100.00
+	Sc
		376762 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		IMB2_YEAST (9-895): 1.68e-104: 346: 31.22
+	Dm
		1095699 Q24024_DROME (11-185): 9.7e-38: 142: 38.83		Q9VN44_DROME (16-896): 1.51e-34: 145: 11.91
+	Dm
		432499 ROA1_DROME (89-192): 4.67e-19: 89.4: 23.08		Q9VN44_DROME (16-896): 1.51e-34: 145: 11.91