HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: SNR40 (Q96DI7)
U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57)
Gene: SNRNP40

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 357
+	Hs
		453251 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		WDR5_HUMAN (95-357): 1.45e-83: 258: 25.09
+	Hs
		162000 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		WDR5_HUMAN (95-357): 1.45e-83: 258: 25.09
+	Hs
		609790 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		WDR5_HUMAN (95-357): 1.45e-83: 258: 25.09
+	Hs
		852006 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		WDR5_HUMAN (95-357): 1.45e-83: 258: 25.09
+	Hs
		903463 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		WDR5_HUMAN (95-357): 1.45e-83: 258: 25.09
+	Hs
		1288230 DAZP1_HUMAN (8-365): 1.46e-57: 194: 24.87		SNR40_HUMAN (143-357): 1.07e-57: 192: 19.73
+	Hs
		162112 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		SNR40_HUMAN (143-357): 1.07e-57: 192: 19.73
+	Hs
		609995 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		SNR40_HUMAN (143-357): 1.07e-57: 192: 19.73
+	Hs
		852133 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		SNR40_HUMAN (143-357): 1.07e-57: 192: 19.73
+	Hs
		453420 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		A16L1_HUMAN (32-344): 8.46e-35: 136: 29.87
+	Mm
		1207730 ROA0_MOUSE (9-186): 4.93e-59: 195: 59.55		A16L1_MOUSE (41-350): 2.91e-34: 134: 29.56
+	Hs
		162071 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		A16L1_HUMAN (32-344): 8.46e-35: 136: 29.87
+	Mm
		825789 ROA1_MOUSE (1-302): 7.42e-58: 192: 86.09		A16L1_MOUSE (41-350): 2.91e-34: 134: 29.56
+	Hs
		609891 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		Q17RG0_HUMAN (32-344): 6.06e-35: 136: 29.87
+	Hs
		609912 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		A16L1_HUMAN (32-344): 8.46e-35: 136: 29.87
+	Mm
		291918 ROA2_MOUSE (1-339): 4.42e-56: 188: 59.29		A16L1_MOUSE (41-350): 2.91e-34: 134: 29.56
+	Hs
		453519 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		FBXW7_HUMAN (53-216): 6.52e-28: 116: 27.17
+	Hs
		609988 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		FBXW7_HUMAN (53-216): 6.52e-28: 116: 27.17
+	Hs
		852125 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		FBXW7_HUMAN (53-216): 6.52e-28: 116: 27.17
+	Hs
		1146775 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		A16L1_HUMAN (32-344): 8.46e-35: 136: 29.87