HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: PUF60 (Q9UHX1)
Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)
Gene: PUF60

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 22446626
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000381 - regulation of alternative mRNA splicing, via spliceosome GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 559
+	Hs
		453360 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		201670 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1054503 DAZP1_HUMAN (8-365): 1.46e-57: 194: 24.87		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1054357 RA1L2_HUMAN (1-302): 4.03e-58: 193: 83.44		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		162048 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		609861 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		453526 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86
+	Hs
		609833 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80
+	Hs
		453511 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		CELF1_HUMAN (98-214): 1.29e-17: 87.5: 26.50
+	Hs
		311334 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		CELF2_HUMAN (116-203): 3.74e-17: 86.5: 31.82
+	Hs
		201689 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		CELF5_HUMAN (226-307): 1.82e-18: 90.2: 25.61
+	Hs
		201697 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		CELF1_HUMAN (98-214): 1.29e-17: 87.5: 26.50
+	Hs
		1272074 DAZP1_HUMAN (8-365): 1.46e-57: 194: 24.87		CELF1_HUMAN (98-214): 1.29e-17: 87.5: 26.50
+	Hs
		162101 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		CELF1_HUMAN (98-214): 1.29e-17: 87.5: 26.50
+	Hs
		609979 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		CELF1_HUMAN (98-214): 1.29e-17: 87.5: 26.50
+	Hs
		453331 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		453107 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Hs
		162035 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		161948 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Hs
		516358 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64