HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: RBM7 (Q9Y580)
RNA-binding protein 7 (RNA-binding motif protein 7)
Gene: RBM7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 22446626
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000381 - regulation of alternative mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0003727 - single-stranded RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 266
+	Hs
		453331 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP4_HUMAN (4-262): 1.83e-39: 146: 15.14
+	Hs
		453107 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP1_HUMAN (4-256): 1.02e-38: 144: 14.71
+	Hs
		162035 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP4_HUMAN (4-262): 1.83e-39: 146: 15.14
+	Hs
		161948 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP1_HUMAN (4-256): 1.02e-38: 144: 14.71
+	Hs
		516358 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		PABP1_HUMAN (4-256): 1.02e-38: 144: 14.71
+	Hs
		516424 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		PABP1_HUMAN (4-256): 1.02e-38: 144: 14.71
+	Sc
		376562 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		PABP_YEAST (10-258): 4.72e-37: 139: 15.22
+	Hs
		609833 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		ELAV2_HUMAN (2-205): 9.2e-23: 97.4: 16.09
+	Hs
		516689 PABP3_HUMAN (6-193): 6.86e-35: 137: 17.90		PABP1_HUMAN (4-256): 1.02e-38: 144: 14.71
+	Hs
		516663 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		PABP1_HUMAN (4-256): 1.02e-38: 144: 14.71
+	Hs
		609862 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		ELAV3_HUMAN (2-216): 6.03e-19: 87: 15.14
+	Hs
		1020249 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		PABP4_HUMAN (4-262): 1.83e-39: 146: 15.14
+	Hs
		516484 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		PABP1_HUMAN (4-256): 1.02e-38: 144: 14.71
+	Hs
		1020319 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		ELAV2_HUMAN (2-205): 9.2e-23: 97.4: 16.09
+	Hs
		516511 HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00		PABP1_HUMAN (4-256): 1.02e-38: 144: 14.71
+	Hs
		474019 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		PAB4L_HUMAN (4-171): 1.42e-33: 126: 14.52
+	Sc
		376694 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		PUB1_YEAST (6-108): 4.83e-15: 76.3: 30.10
+	Sc
		376645 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		RNA15_YEAST (10-88): 8.43e-15: 74.4: 33.75
+	Hs
		1020259 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		ELAV3_HUMAN (2-216): 6.03e-19: 87: 15.14
+	Hs
		680450 HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00		TIA1_HUMAN (3-187): 4.56e-17: 81.7: 15.43