HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: IF2B2 (Q9Y6M1)
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2)
Gene: IGF2BP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	25324306, 34079125, 17643375
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003730 - mRNA 3'-UTR binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0051028 - mRNA transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 599
+	Hs
		128000 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		IF2B3_HUMAN (2-599): 4.89e-134: 405: 62.36
+	Hs
		453668 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		IF2B1_HUMAN (2-599): 2.29e-130: 395: 63.89
+	Hs
		128025 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		IF2B3_HUMAN (2-599): 4.89e-134: 405: 62.36
+	Hs
		162175 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		IF2B1_HUMAN (2-599): 2.29e-130: 395: 63.89
+	Hs
		453375 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PCBP2_HUMAN (422-597): 7.25e-36: 140: 26.92
+	Hs
		453542 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		FUBP3_HUMAN (196-414): 3.06e-18: 90.2: 15.51
+	Hs
		453252 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		HNRPK_HUMAN (386-596): 5.84e-18: 88.9: 17.09
+	Hs
		1290128 DAZP1_HUMAN (8-365): 1.46e-57: 194: 24.87		FUBP3_HUMAN (196-414): 3.06e-18: 90.2: 15.51
+	Mm
		904332 ROA0_MOUSE (9-186): 4.93e-59: 195: 59.55		HNRPK_MOUSE (386-596): 5.84e-18: 88.9: 17.09
+	Mm
		825776 ROA1_MOUSE (1-302): 7.42e-58: 192: 86.09		HNRPK_MOUSE (386-596): 5.84e-18: 88.9: 17.09
+	Hs
		162001 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		HNRPK_HUMAN (386-596): 5.84e-18: 88.9: 17.09
+	Hs
		610004 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		FUBP3_HUMAN (196-414): 3.06e-18: 90.2: 15.51
+	Mm
		291908 ROA2_MOUSE (1-339): 4.42e-56: 188: 59.29		HNRPK_MOUSE (386-596): 5.84e-18: 88.9: 17.09
+	Hs
		609791 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		HNRPK_HUMAN (386-596): 5.84e-18: 88.9: 17.09
+	Hs
		453516 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		FUBP2_HUMAN (414-584): 1.07e-10: 66.6: 28.73
+	Hs
		453374 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PCBP1_HUMAN (422-530): 8.21e-11: 65.8: 25.69
+	Hs
		201664 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		VIGLN_HUMAN (444-585): 4.33e-12: 71.5: 19.01
+	Hs
		959594 DAZP1_HUMAN (8-365): 1.46e-57: 194: 24.87		VIGLN_HUMAN (444-585): 4.33e-12: 71.5: 19.01
+	Mm
		825779 ROA1_MOUSE (1-302): 7.42e-58: 192: 86.09		FUBP2_MOUSE (414-584): 5.84e-11: 67.4: 28.73
+	Hs
		609880 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		PCBP1_HUMAN (422-530): 8.21e-11: 65.8: 25.69