HitPredict

Interactor 1: RU2A (P09661)
U2 small nuclear ribonucleoprotein A' (U2 snRNP A')
Gene: SNRPA1

Interactor 2: SYF1 (Q9HCS7)
Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2)
Gene: XAB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	26186194, 28514442, 33961781, 25599396
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0071007 - U2-type catalytic step 2 spliceosome GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 855
+	Sp
		1350844 RU2A_SCHPO (2-230): 1.23e-38: 136: 41.60		SYF1_SCHPO (21-772): 2.32e-148: 457: 43.65
+	Sc
		978484 RU2A_YEAST (14-227): 2.09e-31: 117: 24.07		SYF1_YEAST (19-733): 1.86e-87: 298: 22.31
+	Hs
		453901 RU2A_HUMAN (1-255): 9.82e-54: 175: 100.00		CRNL1_HUMAN (166-822): 5.62e-47: 182: 14.51
+	Sp
		953584 RU2A_SCHPO (2-230): 1.23e-38: 136: 41.60		CLF1_SCHPO (471-778): 7.87e-33: 137: 13.61
+	Hs
		174949 TBCEL_HUMAN (21-246): 1.98e-29: 116: 20.32		OGT1_HUMAN (7-468): 1.59e-37: 154: 13.55
+	Hs
		174879 SCRIB_HUMAN (9-248): 4.3e-28: 114: 15.70		OGT1_HUMAN (7-468): 1.59e-37: 154: 13.55
+	Hs
		175318 NISCH_HUMAN (76-225): 4.51e-12: 67.6: 11.92		OGT1_HUMAN (7-468): 1.59e-37: 154: 13.55
+	Hs
		174920 TBCE_HUMAN (16-235): 6.1e-10: 60.7: 15.95		OGT1_HUMAN (7-468): 1.59e-37: 154: 13.55
+	Hs
		174913 PP1R7_HUMAN (24-151): 9.53e-09: 57: 28.91		OGT1_HUMAN (7-468): 1.59e-37: 154: 13.55
+	Hs
		1058022 LGR4_HUMAN (1-217): 5.37e-25: 105: 14.87		RRP5_HUMAN (11-347): 9.5e-18: 90.8: 11.26
+	Sc
		997045 RU2A_YEAST (14-227): 2.09e-31: 117: 24.07		CLF1_YEAST (3-250): 5.35e-11: 68.5: 12.06