HitPredict

Interactor 1: FGR (P09769)
Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)
Gene: FGR

Interactor 2: HCLS1 (P14317)
Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75)
Gene: HCLS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10066823
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 529 Hs			1 486
+	Mm
		763381 FYN_MOUSE (1-527): 0: 607: 69.76		HCLS1_MOUSE (1-485): 9.6e-134: 397: 80.53
+	Hs
		522981 SRC_HUMAN (1-527): 0: 602: 65.74		SRC8_HUMAN (1-486): 5.55e-127: 382: 39.86
+	Hs
		433350 YES_HUMAN (1-527): 0: 596: 67.83		SRC8_HUMAN (1-486): 5.55e-127: 382: 39.86
+	Hs
		433551 LYN_HUMAN (1-524): 0: 553: 53.91		HCLS1_HUMAN (1-486): 9.61e-143: 420: 100.00
+	Mm
		411921 LCK_MOUSE (1-526): 0: 569: 51.90		HCLS1_MOUSE (1-485): 9.6e-134: 397: 80.53
+	Mm
		639438 LYN_MOUSE (1-524): 0: 556: 53.89		HCLS1_MOUSE (1-485): 9.6e-134: 397: 80.53
+	Mm
		639446 LYN_MOUSE (1-524): 0: 556: 53.89		SRC8_MOUSE (1-486): 5.07e-128: 384: 40.88
+	Mm
		763400 FYN_MOUSE (1-527): 0: 607: 69.76		PLCG2_MOUSE (56-485): 1.46e-44: 169: 15.39
+	Hs
		411992 FYN_HUMAN (1-527): 0: 607: 69.94		PLCG2_HUMAN (56-485): 1.3e-43: 167: 15.39
+	Hs
		412000 FYN_HUMAN (1-527): 0: 607: 69.94		PLCG1_HUMAN (55-485): 1.1e-40: 158: 17.41
+	Hs
		522758 SRC_HUMAN (1-527): 0: 602: 65.74		PLCG1_HUMAN (55-485): 1.1e-40: 158: 17.41
+	Hs
		412404 FYN_HUMAN (1-527): 0: 607: 69.94		ASAP1_HUMAN (206-485): 2.99e-35: 142: 18.25
+	Hs
		523197 SRC_HUMAN (1-527): 0: 602: 65.74		ASAP1_HUMAN (206-485): 2.99e-35: 142: 18.25
+	Hs
		412328 FYN_HUMAN (1-527): 0: 607: 69.94		SH3G2_HUMAN (180-485): 1.31e-31: 126: 15.74
+	Hs
		411715 LCK_HUMAN (1-526): 0: 559: 51.90		SPTN1_HUMAN (32-486): 3.87e-44: 169: 14.41
+	Mm
		639456 LYN_MOUSE (1-524): 0: 556: 53.89		PLCG2_MOUSE (56-485): 1.46e-44: 169: 15.39
+	Hs
		433564 LYN_HUMAN (1-524): 0: 553: 53.91		PLCG2_HUMAN (56-485): 1.3e-43: 167: 15.39
+	Hs
		442894 HCK_HUMAN (1-524): 0: 568: 56.30		ASAP1_HUMAN (206-485): 2.99e-35: 142: 18.25
+	Mm
		639449 LYN_MOUSE (1-524): 0: 556: 53.89		DBNL_MOUSE (144-486): 5.96e-35: 137: 21.97
+	Hs
		433732 LYN_HUMAN (1-524): 0: 553: 53.91		MYO1E_HUMAN (217-485): 1.81e-34: 139: 18.22