HitPredict

Interactor 1: FGR (P09769)
Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)
Gene: FGR

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.738

Property	Details
Experiments	11071635, 22974441
Identification Methods	pull down, unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 529 Hs			1 481
+	Hs
		523124 SRC_HUMAN (1-527): 0: 602: 65.74		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		433460 YES_HUMAN (1-527): 0: 596: 67.83		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		442876 HCK_HUMAN (1-524): 0: 568: 56.30		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		433966 LYN_HUMAN (1-524): 0: 553: 53.91		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Mm
		639441 LYN_MOUSE (1-524): 0: 556: 53.89		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Mm
		250949 SRC_MOUSE (1-527): 0: 608: 65.67		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		235036 FYN_HUMAN (1-527): 0: 607: 69.94		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		235040 SRC_HUMAN (1-527): 0: 602: 65.74		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		235037 YES_HUMAN (1-527): 0: 596: 67.83		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Mm
		250950 LYN_MOUSE (1-524): 0: 556: 53.89		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		235035 LCK_HUMAN (1-526): 0: 559: 51.90		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		151689 LCK_HUMAN (1-526): 0: 559: 51.90		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		412057 FYN_HUMAN (1-527): 0: 607: 69.94		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Hs
		151692 LYN_HUMAN (1-524): 0: 553: 53.91		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Mm
		403453 SRC_MOUSE (1-527): 0: 608: 65.67		FRS2_MOUSE (154-464): 4.46e-56: 196: 21.73
+	Mm
		639440 LYN_MOUSE (1-524): 0: 556: 53.89		IRS2_MOUSE (6-371): 1.55e-70: 245: 15.10
+	Dm
		1360394 SRC42_DROME (1-525): 0: 552: 52.16		Q9W3R6_DROME (1-256): 8.47e-59: 206: 25.75
+	Hs
		207290 HCK_HUMAN (1-524): 0: 568: 56.30		FRS3_HUMAN (153-432): 4e-52: 185: 20.42
+	Hs
		411805 LCK_HUMAN (1-526): 0: 559: 51.90		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09
+	Hs
		433914 LYN_HUMAN (1-524): 0: 553: 53.91		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09