HitPredict

Interactor 1: AST8 (P09775)
Achaete-scute complex protein T8 (Protein asense)
Gene: ase

Interactor 2: ESMB (Q01069)
Enhancer of split mbeta protein (E(spl)mbeta) (HLH-mbeta) (Split locus enhancer protein mA)
Gene: E(spl)mbeta-HLH

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	9371806
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0007399 - nervous system development GO:0022416 - chaeta development GO:0050767 - regulation of neurogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 486 Dm			1 195
+	Dm
		454873 AST8_DROME (1-486): 0: 642: 100.00		ESMC_DROME (6-195): 3.24e-52: 168: 50.00
+	Dm
		454869 AST8_DROME (1-486): 0: 642: 100.00		ESM7_DROME (1-195): 1.93e-48: 157: 44.55
+	Dm
		454871 AST8_DROME (1-486): 0: 642: 100.00		ESM3_DROME (5-195): 1.09e-46: 154: 40.81
+	Dm
		485926 AST4_DROME (105-241): 7.1e-28: 115: 37.96		ESMB_DROME (1-195): 7.43e-69: 210: 100.00
+	Dm
		485927 AST4_DROME (105-241): 7.1e-28: 115: 37.96		ESMC_DROME (6-195): 3.24e-52: 168: 50.00
+	Dm
		485919 AST4_DROME (105-241): 7.1e-28: 115: 37.96		ESM8_DROME (7-195): 1.39e-51: 165: 35.45
+	Dm
		485918 AST4_DROME (105-241): 7.1e-28: 115: 37.96		ESM7_DROME (1-195): 1.93e-48: 157: 44.55
+	Dm
		485925 AST4_DROME (105-241): 7.1e-28: 115: 37.96		ESM3_DROME (5-195): 1.09e-46: 154: 40.81
+	Dm
		485887 AST5_DROME (151-231): 1.56e-23: 99: 54.22		ESM8_DROME (7-195): 1.39e-51: 165: 35.45
+	Dm
		485886 AST5_DROME (151-231): 1.56e-23: 99: 54.22		ESM7_DROME (1-195): 1.93e-48: 157: 44.55
+	Dm
		485917 AST4_DROME (105-241): 7.1e-28: 115: 37.96		ESM5_DROME (8-195): 9.82e-42: 140: 31.58
+	Dm
		485891 AST5_DROME (151-231): 1.56e-23: 99: 54.22		ESM3_DROME (5-195): 1.09e-46: 154: 40.81
+	Hs
		1294221 NGN3_HUMAN (71-270): 5.79e-30: 118: 16.43		HES6_HUMAN (9-195): 2.21e-36: 128: 21.46
+	Mm
		1142076 HAND2_MOUSE (111-268): 1.25e-24: 103: 24.68		HEY2_MOUSE (7-191): 1.17e-40: 142: 23.68
+	Hs
		330433 HAND1_HUMAN (91-265): 2.78e-24: 102: 21.71		HEY2_HUMAN (7-191): 4.06e-41: 143: 24.21
+	Mm
		1142077 HAND2_MOUSE (111-268): 1.25e-24: 103: 24.68		HEY1_MOUSE (7-191): 5.57e-41: 141: 21.69
+	Mm
		1142075 HAND2_MOUSE (111-268): 1.25e-24: 103: 24.68		HEYL_MOUSE (9-190): 7.47e-39: 137: 24.32
+	Dm
		485885 AST5_DROME (151-231): 1.56e-23: 99: 54.22		ESM5_DROME (8-195): 9.82e-42: 140: 31.58
+	Hs
		330432 HAND1_HUMAN (91-265): 2.78e-24: 102: 21.71		HEYL_HUMAN (7-188): 1.44e-37: 133: 23.24
+	Rn
		583274 ASCL1_RAT (113-275): 1.05e-27: 112: 34.36		HES5_RAT (3-195): 2.56e-34: 121: 21.76