HitPredict

Interactor 1: C1S (P09871)
Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain]
Gene: C1S

Interactor 2: CO4B (P0C0L5)
Complement C4-B (Basic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3) [Cleaved into: Complement C4 beta chain; Complement C4-B alpha chain; C4a anaphylatoxin; C4b-B; C4d-B; Complement C4 gamma chain]
Gene: C4B

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9422791
Identification Methods	protease assay
Interaction Type	cleavage reaction

Property	Details
Interacting Pfam domains	A2M~Sushi, A2M_BRD~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement, A2M_recep~Trypsin, MG2~Trypsin
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006958 - complement activation, classical pathway GO:0045087 - innate immune response GO:0072562 - blood microparticle
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 688 Hs			1 1744
+	Hs
		455002 C1S_HUMAN (1-688): 0: 599: 100.00		CO4A_HUMAN (1-1744): 0: 2073: 99.43
+	Hs
		469849 MASP1_HUMAN (3-683): 6.09e-180: 530: 34.04		CO4A_HUMAN (1-1744): 0: 2073: 99.43
+	Hs
		469901 MASP1_HUMAN (3-683): 6.09e-180: 530: 34.04		CO4B_HUMAN (1-1744): 0: 2072: 100.00
+	Hs
		119683 MASP2_HUMAN (3-681): 7.28e-169: 501: 36.69		CO4A_HUMAN (1-1744): 0: 2073: 99.43
+	Hs
		119684 MASP2_HUMAN (3-681): 7.28e-169: 501: 36.69		CO4B_HUMAN (1-1744): 0: 2072: 100.00
+	Hs
		344649 MASP1_HUMAN (3-683): 6.09e-180: 530: 34.04		CO3_HUMAN (20-1742): 0: 1527: 27.92
+	Hs
		119680 MASP2_HUMAN (3-681): 7.28e-169: 501: 36.69		CO3_HUMAN (20-1742): 0: 1527: 27.92