Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 22362888, 24636898, 25673562, 27067600, 28190768, 26356822, 31911551, 35219381, 35013556, 35637285, 16204234, 15737996, 20388712, 17283121, 14734561, 22683995, 23481255
Identification Methods enzymatic study, pull down, affinity chromatography technology, proximity labelling technology, x-ray crystallography
Interaction Type direct interaction, physical association, association, adp ribosylation reaction, enzymatic reaction

The annotation score is based on:

Property Details
Interacting Pfam domains BRCT~BRCT, PADR1~PARP_reg, PADR1~zf-PARP, PARP~PARP, PARP~PARP_reg, PARP_reg~PARP_reg, PARP_reg~WGR, WGR~zf-PARP, zf-PARP~zf-PARP
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000723 - telomere maintenance
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0003677 - DNA binding
and 95 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 1014
Hs

1 1014
+ Dm
+ Hs
+ At
+ Hs
+ Hs
+ At
+ Hs
+ Mm
+ At
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024