Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1
Interactor 2: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.97 | 1.00 | 0.987 |
The method score is based on:
Property | Details |
---|---|
Experiments | 22362888, 24636898, 25673562, 27067600, 28190768, 26356822, 31911551, 35219381, 35013556, 35637285, 16204234, 15737996, 20388712, 17283121, 14734561, 22683995, 23481255 |
Identification Methods | enzymatic study, pull down, affinity chromatography technology, proximity labelling technology, x-ray crystallography |
Interaction Type | direct interaction, physical association, association, adp ribosylation reaction, enzymatic reaction |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | BRCT~BRCT, PADR1~PARP_reg, PADR1~zf-PARP, PARP~PARP, PARP~PARP_reg, PARP_reg~PARP_reg, PARP_reg~WGR, WGR~zf-PARP, zf-PARP~zf-PARP |
Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000723 - telomere maintenance GO:0000781 - chromosome, telomeric region GO:0000785 - chromatin GO:0003677 - DNA binding and 95 others more... |
Homologous interactions | 16 |
Homologous interactions
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024