HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	34079125, 28190768, 37071682
Identification Methods	proximity labelling technology, enzymatic study, cross-linking study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1014 Hs			1 126
+	Hs
		455094 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41
+	Hs
		455500 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		455733 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21
+	Hs
		455136 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62
+	Hs
		455276 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2B1D_HUMAN (1-126): 3.24e-53: 164: 99.21
+	Hs
		455645 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2B3B_HUMAN (1-126): 8.29e-52: 161: 95.24
+	Hs
		455738 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2B1A_HUMAN (1-126): 3.14e-46: 147: 84.25
+	Dm
		355257 PARP_DROME (6-1009): 0: 1046: 41.29		H2B_DROME (36-126): 9.18e-47: 148: 94.51
+	Hs
		1087460 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		918755 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Hs
		707781 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62
+	Hs
		1231259 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2B3B_HUMAN (1-126): 8.29e-52: 161: 95.24
+	Hs
		1282979 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2B1A_HUMAN (1-126): 3.14e-46: 147: 84.25
+	Hs
		1087515 PARP3_HUMAN (485-1005): 1.45e-147: 451: 31.87		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		617984 PARP4_HUMAN (402-1007): 2.13e-125: 421: 22.81		H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41
+	Hs
		1274474 PARP4_HUMAN (402-1007): 2.13e-125: 421: 22.81		H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21
+	Hs
		241659 PARP4_HUMAN (402-1007): 2.13e-125: 421: 22.81		H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21
+	Hs
		836703 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Hs
		836738 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		707557 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62