HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: MYO1E (Q12965)
Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E)
Gene: MYO1E

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	35271311, 35013556
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1014 Hs			1 1108
+	Hs
		455991 PARP1_HUMAN (1-1014): 0: 1362: 100.00		MYO5B_HUMAN (8-1063): 0: 993: 26.25
+	Hs
		1021715 PARP2_HUMAN (514-1014): 0: 594: 41.72		MYO1E_HUMAN (1-1108): 0: 1198: 100.00
+	Hs
		1021678 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		MYO1E_HUMAN (1-1108): 0: 1198: 100.00
+	Hs
		297427 PARP2_HUMAN (514-1014): 0: 594: 41.72		MYO1D_HUMAN (20-719): 0: 569: 42.54
+	Hs
		297373 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		MYO1D_HUMAN (20-719): 0: 569: 42.54
+	Hs
		117743 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		MYO1C_HUMAN (698-843): 2e-10: 67.4: 31.76
+	Hs
		1189103 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		MYO5A_HUMAN (689-1083): 5.07e-09: 62.8: 7.24