HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: KLF5 (Q13887)
Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2)
Gene: KLF5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	17283079
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1014 Hs			1 457
+	Hs
		316774 PARP1_HUMAN (1-1014): 0: 1362: 100.00		KLF8_HUMAN (366-455): 4.48e-40: 149: 78.89
+	Hs
		434906 PARP1_HUMAN (1-1014): 0: 1362: 100.00		SP1_HUMAN (362-457): 3.21e-26: 114: 57.29
+	Hs
		836698 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		KLF3_HUMAN (308-455): 2.48e-37: 141: 59.33
+	Hs
		204193 ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71		KLF4_HUMAN (361-455): 3e-34: 135: 75.79