HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: PARPT (Q7Z3E1)
Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) (TCDD-inducible poly [ADP-ribose] polymerase)
Gene: TIPARP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35439318
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PARP~PARP, PARP~PARP_reg
Common GO terms	GO:0003950 - NAD+ ADP-ribosyltransferase activity GO:0005634 - nucleus GO:0016779 - nucleotidyltransferase activity GO:1990404 - NAD+-protein ADP-ribosyltransferase activity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1014 Hs			1 657
+	Hs
		455634 PARP1_HUMAN (1-1014): 0: 1362: 100.00		PARP9_HUMAN (455-650): 2.55e-64: 229: 25.76
+	Hs
		1188487 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		PARPT_HUMAN (1-657): 0: 1089: 100.00
+	Hs
		836746 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		PARPT_HUMAN (1-657): 0: 1089: 100.00
+	Hs
		1187636 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		ZCCHV_HUMAN (202-650): 1.19e-147: 452: 26.47
+	Mm
		1207488 PAR12_MOUSE (688-1006): 5.29e-46: 179: 15.88		PAR12_MOUSE (229-652): 2.75e-165: 492: 31.00
+	Hs
		1344068 PAR11_HUMAN (773-1005): 1.38e-50: 183: 12.69		PAR11_HUMAN (345-648): 3.47e-114: 347: 29.72
+	Hs
		310030 TNKS1_HUMAN (639-1012): 2.38e-74: 270: 18.53		TNKS1_HUMAN (459-651): 4.77e-52: 196: 23.29
+	Hs
		1329533 TNKS2_HUMAN (639-1013): 1.1e-71: 261: 17.86		TNKS2_HUMAN (439-651): 4.71e-54: 202: 22.59
+	Hs
		1115182 PAR14_HUMAN (772-1006): 5.76e-36: 150: 14.29		PARP9_HUMAN (455-650): 2.55e-64: 229: 25.76
+	Hs
		1115175 PAR14_HUMAN (772-1006): 5.76e-36: 150: 14.29		PAR10_HUMAN (467-651): 1.67e-61: 223: 34.39
+	Hs
		1120923 PAR10_HUMAN (801-1004): 1.15e-19: 97.3: 12.62		PAR10_HUMAN (467-651): 1.67e-61: 223: 34.39