HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: H2A1C (Q93077)
Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l)
Gene: H2AC6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 37071682
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1014 Hs			1 130
+	Hs
		455554 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2A2A_HUMAN (1-130): 9.4e-68: 202: 98.46
+	Hs
		391516 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2A1B_HUMAN (1-130): 1.52e-67: 201: 98.46
+	Hs
		455012 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2A1_HUMAN (1-130): 1.29e-67: 201: 98.46
+	Hs
		455802 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2A1J_HUMAN (1-128): 5.32e-67: 200: 97.66
+	Hs
		455622 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2A2B_HUMAN (1-130): 3.14e-66: 198: 95.39
+	Hs
		455818 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2AJ_HUMAN (1-126): 8.72e-65: 194: 96.03
+	Hs
		455054 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2AX_HUMAN (1-130): 1.1e-63: 192: 89.55
+	Dm
		728986 PARP_DROME (6-1009): 0: 1046: 41.29		H2A_DROME (17-125): 1.09e-59: 181: 90.83
+	Hs
		1151393 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2A2A_HUMAN (1-130): 9.4e-68: 202: 98.46
+	Hs
		391953 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2A1B_HUMAN (1-130): 1.52e-67: 201: 98.46
+	Hs
		470599 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2A1_HUMAN (1-130): 1.29e-67: 201: 98.46
+	Hs
		1087127 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2A2C_HUMAN (1-130): 5.75e-65: 194: 96.92
+	Hs
		555678 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2AX_HUMAN (1-130): 1.1e-63: 192: 89.55
+	Hs
		391601 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H2A1B_HUMAN (1-130): 1.52e-67: 201: 98.46
+	Hs
		470301 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H2A1_HUMAN (1-130): 1.29e-67: 201: 98.46
+	Hs
		836737 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H2A2C_HUMAN (1-130): 5.75e-65: 194: 96.92
+	Hs
		555353 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H2AX_HUMAN (1-130): 1.1e-63: 192: 89.55
+	Hs
		470434 ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71		H2A1_HUMAN (1-130): 1.29e-67: 201: 98.46
+	Hs
		555522 ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71		H2AX_HUMAN (1-130): 1.1e-63: 192: 89.55
+	Hs
		1087011 PAR10_HUMAN (801-1004): 1.15e-19: 97.3: 12.62		H2A2C_HUMAN (1-130): 5.75e-65: 194: 96.92