HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: H2B1A (Q96A08)
Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B)
Gene: H2BC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	26186194, 28514442, 20525793
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1014 Hs			1 127
+	Hs
		455094 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2B1O_HUMAN (5-127): 3.41e-54: 167: 86.18
+	Hs
		455500 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		455136 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		455276 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2B1D_HUMAN (1-127): 1.37e-53: 166: 85.04
+	Hs
		455301 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		455733 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2B1H_HUMAN (5-127): 5.52e-54: 166: 85.37
+	Hs
		455645 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2B3B_HUMAN (1-127): 8.98e-51: 158: 85.83
+	Dm
		355257 PARP_DROME (6-1009): 0: 1046: 41.29		H2B_DROME (37-127): 3.48e-47: 149: 94.51
+	Hs
		1087460 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		707781 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		918755 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		1282979 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2B1A_HUMAN (1-127): 1.72e-52: 163: 100.00
+	Hs
		1231259 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2B3B_HUMAN (1-127): 8.98e-51: 158: 85.83
+	Hs
		1087515 PARP3_HUMAN (485-1005): 1.45e-147: 451: 31.87		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		617984 PARP4_HUMAN (402-1007): 2.13e-125: 421: 22.81		H2B1O_HUMAN (5-127): 3.41e-54: 167: 86.18
+	Hs
		1274474 PARP4_HUMAN (402-1007): 2.13e-125: 421: 22.81		H2B1H_HUMAN (5-127): 5.52e-54: 166: 85.37
+	Hs
		241659 PARP4_HUMAN (402-1007): 2.13e-125: 421: 22.81		H2B1K_HUMAN (1-127): 8.56e-54: 166: 84.25
+	Hs
		836738 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		707557 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		836703 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04