HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: CHFR (Q96EP1)
E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196) (RING-type E3 ubiquitin transferase CHFR)
Gene: CHFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.743

Property	Details
Experiments	19182791, 23268447, 26356822, 31616951, 22337872, 35271311, 18172500
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1014 Hs			1 664
+	Hs
		282496 PARP1_HUMAN (1-1014): 0: 1362: 100.00		RNF8_HUMAN (37-385): 7.97e-108: 336: 19.15
+	Hs
		455143 PARP1_HUMAN (1-1014): 0: 1362: 100.00		BMI1_HUMAN (287-438): 5.06e-39: 148: 19.62
+	Hs
		455144 PARP1_HUMAN (1-1014): 0: 1362: 100.00		PCGF2_HUMAN (287-477): 1.09e-34: 136: 17.26
+	Hs
		455789 PARP1_HUMAN (1-1014): 0: 1362: 100.00		RING2_HUMAN (274-441): 1.28e-32: 130: 15.39
+	Hs
		718293 PARP4_HUMAN (402-1007): 2.13e-125: 421: 22.81		BMI1_HUMAN (287-438): 5.06e-39: 148: 19.62
+	Hs
		1188794 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		PCGF1_HUMAN (287-433): 3.8e-37: 141: 18.30
+	Hs
		1188819 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		PCGF6_HUMAN (279-410): 5.03e-36: 140: 22.46
+	Hs
		987984 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		RING1_HUMAN (268-455): 9.62e-35: 138: 17.14
+	Hs
		1188765 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		RING2_HUMAN (274-441): 1.28e-32: 130: 15.39
+	Hs
		718184 PAR12_HUMAN (771-1005): 6.79e-46: 178: 15.73		BMI1_HUMAN (287-438): 5.06e-39: 148: 19.62
+	Hs
		1304096 PAR12_HUMAN (771-1005): 6.79e-46: 178: 15.73		RING2_HUMAN (274-441): 1.28e-32: 130: 15.39
+	Hs
		717568 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		BMI1_HUMAN (287-438): 5.06e-39: 148: 19.62
+	Hs
		717967 ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71		BMI1_HUMAN (287-438): 5.06e-39: 148: 19.62
+	Hs
		1187729 ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71		RING2_HUMAN (274-441): 1.28e-32: 130: 15.39