HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: COR1B (Q9BR76)
Coronin-1B (Coronin-2)
Gene: CORO1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 35013556
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1014 Hs			1 489
+	Hs
		455993 PARP1_HUMAN (1-1014): 0: 1362: 100.00		COR1C_HUMAN (4-484): 1.14e-119: 360: 72.77
+	Hs
		455290 PARP1_HUMAN (1-1014): 0: 1362: 100.00		WDR5_HUMAN (4-111): 3.06e-15: 78.8: 15.46
+	Hs
		1188787 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		COR1B_HUMAN (1-489): 1.7e-130: 388: 100.00
+	Ce
		954092 TNKS1_CAEEL (485-1006): 8.69e-140: 465: 22.80		LIN53_CAEEL (30-165): 4.88e-16: 82.1: 18.88
+	Hs
		1288300 TNKS2_HUMAN (639-1013): 1.1e-71: 261: 17.86		SNR40_HUMAN (252-488): 2.91e-20: 93.9: 9.13
+	Hs
		1083293 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		RBBP7_HUMAN (31-163): 1.15e-16: 84: 21.43
+	Hs
		997781 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		RBBP4_HUMAN (31-163): 1.65e-15: 80.5: 20.00
+	Hs
		903333 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		WDR5_HUMAN (4-111): 3.06e-15: 78.8: 15.46
+	Hs
		1188826 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		TBL1R_HUMAN (66-238): 3.52e-11: 67.4: 27.87
+	Hs
		884643 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		CORO7_HUMAN (1-162): 1.07e-10: 66.2: 13.45
+	Hs
		245615 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		TBL1X_HUMAN (66-238): 4.93e-10: 63.9: 28.26
+	Hs
		903273 PAR14_HUMAN (772-1006): 5.76e-36: 150: 14.29		WDR5_HUMAN (4-111): 3.06e-15: 78.8: 15.46