HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: SMRCD (Q9H4L7)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1)
Gene: SMARCAD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 21549307
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035861 - site of double-strand break and 1 others more... GO:0043596 - nuclear replication fork
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1014 Hs			1 1026
+	Hs
		455239 PARP1_HUMAN (1-1014): 0: 1362: 100.00		SMCA4_HUMAN (96-1024): 0: 693: 26.54
+	Hs
		455238 PARP1_HUMAN (1-1014): 0: 1362: 100.00		SMCA2_HUMAN (55-1024): 0: 689: 25.05
+	Hs
		455957 PARP1_HUMAN (1-1014): 0: 1362: 100.00		CHD7_HUMAN (23-1021): 0: 683: 22.57
+	Mm
		503189 PARP1_MOUSE (1-1014): 0: 1339: 92.01		SMCA4_MOUSE (96-1024): 0: 692: 26.43
+	Hs
		455681 PARP1_HUMAN (1-1014): 0: 1362: 100.00		CHD6_HUMAN (61-1021): 0: 664: 22.13
+	Hs
		455374 PARP1_HUMAN (1-1014): 0: 1362: 100.00		CHD3_HUMAN (338-1022): 0: 621: 27.64
+	Hs
		455344 PARP1_HUMAN (1-1014): 0: 1362: 100.00		ERCC6_HUMAN (21-1021): 0: 595: 20.53
+	Hs
		229285 PARP1_HUMAN (1-1014): 0: 1362: 100.00		SMCA5_HUMAN (353-1021): 0: 594: 29.60
+	Hs
		455119 PARP1_HUMAN (1-1014): 0: 1362: 100.00		SMCA1_HUMAN (379-1021): 0: 590: 29.56
+	Hs
		455912 PARP1_HUMAN (1-1014): 0: 1362: 100.00		HELLS_HUMAN (479-999): 1.2e-93: 318: 37.59
+	Dm
		728991 PARP_DROME (6-1009): 0: 1046: 41.29		ISWI_DROME (488-1005): 0: 623: 36.40
+	Hs
		1188861 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		SMRCD_HUMAN (1-1026): 0: 903: 100.00
+	Hs
		847004 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		SMCA4_HUMAN (96-1024): 0: 693: 26.54
+	Hs
		1188971 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		CHD7_HUMAN (23-1021): 0: 683: 22.57
+	Hs
		1188598 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		CHD6_HUMAN (61-1021): 0: 664: 22.13
+	Hs
		1188892 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		CHD8_HUMAN (181-1021): 0: 641: 23.28
+	Hs
		1018552 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		CHD3_HUMAN (338-1022): 0: 621: 27.64
+	Hs
		229429 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		SMCA5_HUMAN (353-1021): 0: 594: 29.60
+	Hs
		658695 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		SMCA1_HUMAN (379-1021): 0: 590: 29.56
+	Hs
		1188919 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		HELLS_HUMAN (479-999): 1.2e-93: 318: 37.59