HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: BRD7 (Q9NPI1)
Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1)
Gene: BRD7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	30940648
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1014 Hs			1 651
+	Hs
		455836 PARP1_HUMAN (1-1014): 0: 1362: 100.00		CECR2_HUMAN (79-519): 1.47e-52: 198: 17.62
+	Hs
		455363 PARP1_HUMAN (1-1014): 0: 1362: 100.00		EP300_HUMAN (42-251): 3.1e-41: 164: 22.02
+	Hs
		455721 PARP1_HUMAN (1-1014): 0: 1362: 100.00		CBP_HUMAN (25-238): 1.58e-39: 158: 23.11
+	Hs
		455699 PARP1_HUMAN (1-1014): 0: 1362: 100.00		PHIP_HUMAN (115-637): 1.3e-38: 155: 12.74
+	Hs
		455103 PARP1_HUMAN (1-1014): 0: 1362: 100.00		BRD2_HUMAN (115-424): 3.01e-33: 138: 15.39
+	Hs
		455371 PARP1_HUMAN (1-1014): 0: 1362: 100.00		BPTF_HUMAN (133-233): 1.15e-18: 93: 29.52
+	Hs
		1342818 PARP2_HUMAN (514-1014): 0: 594: 41.72		BRD7_HUMAN (1-651): 1.84e-168: 498: 100.00
+	Hs
		1188899 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		BRD7_HUMAN (1-651): 1.84e-168: 498: 100.00
+	Hs
		836785 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		BRD7_HUMAN (1-651): 1.84e-168: 498: 100.00
+	Hs
		1187796 ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71		BRD7_HUMAN (1-651): 1.84e-168: 498: 100.00
+	Hs
		998843 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		EP300_HUMAN (42-251): 3.1e-41: 164: 22.02
+	Hs
		1188652 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		CBP_HUMAN (25-238): 1.58e-39: 158: 23.11
+	Hs
		600174 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		TAF1_HUMAN (58-534): 1.25e-34: 143: 13.99
+	Hs
		1189004 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		BAZ2A_HUMAN (70-240): 3.27e-19: 94.9: 22.65
+	Hs
		1017317 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		BPTF_HUMAN (133-233): 1.15e-18: 93: 29.52
+	Hs
		631377 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		BRD2_HUMAN (115-424): 3.01e-33: 138: 15.39
+	Hs
		998842 ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71		EP300_HUMAN (42-251): 3.1e-41: 164: 22.02