HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: RN146 (Q9NTX7)
E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)
Gene: RNF146

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.726

Property	Details
Experiments	35271311, 26186194, 28514442, 21825151, 21799911
Identification Methods	affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0008270 - zinc ion binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1014 Hs			1 359
+	Hs
		1345813 PARP2_HUMAN (514-1014): 0: 594: 41.72		RN146_HUMAN (1-359): 0: 605: 100.00
+	Hs
		310097 TNKS1_HUMAN (639-1012): 2.38e-74: 270: 18.53		RN146_HUMAN (1-359): 0: 605: 100.00
+	Hs
		1329535 TNKS2_HUMAN (639-1013): 1.1e-71: 261: 17.86		RN146_HUMAN (1-359): 0: 605: 100.00
+	Hs
		836788 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		RN146_HUMAN (1-359): 0: 605: 100.00